Disseminated Cryptococcosis in an Immunocompetent Child

Disseminated cryptococcosis in children is a classic affliction associated with human immunodeficiency virus (HIV) infection or primary inherited immunodeficiency disorders (PID) with central nervous system being the most common site of dissemination. We report a rare case of disseminated cryptococc...

Descripción completa

Detalles Bibliográficos
Autores principales: Vijayasekharan, Kalasekhar, Gupta, Nitin, Reddisetti, Suhas, Saravu, Kavitha, Godkhindi, Vishwapriya M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245827/
https://www.ncbi.nlm.nih.gov/pubmed/34239794
http://dx.doi.org/10.7759/cureus.15362
Descripción
Sumario:Disseminated cryptococcosis in children is a classic affliction associated with human immunodeficiency virus (HIV) infection or primary inherited immunodeficiency disorders (PID) with central nervous system being the most common site of dissemination. We report a rare case of disseminated cryptococcosis in an 11-year-old girl who presented with pulmonary involvement, hepatosplenomegaly, and generalized lymphadenopathy. No known inherited or acquired immune deficiencies were identified after a comprehensive laboratory work-up including genetic sequencing. She responded well to anti-fungal therapy (flucytosine and amphotericin followed by fluconazole) and is on regular follow-up. 

Ejemplares similares