Disseminated Cryptococcosis in an Immunocompetent Child

Disseminated cryptococcosis in children is a classic affliction associated with human immunodeficiency virus (HIV) infection or primary inherited immunodeficiency disorders (PID) with central nervous system being the most common site of dissemination. We report a rare case of disseminated cryptococc...

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Autores principales: Vijayasekharan, Kalasekhar, Gupta, Nitin, Reddisetti, Suhas, Saravu, Kavitha, Godkhindi, Vishwapriya M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245827/
https://www.ncbi.nlm.nih.gov/pubmed/34239794
http://dx.doi.org/10.7759/cureus.15362
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author Vijayasekharan, Kalasekhar
Gupta, Nitin
Reddisetti, Suhas
Saravu, Kavitha
Godkhindi, Vishwapriya M
author_facet Vijayasekharan, Kalasekhar
Gupta, Nitin
Reddisetti, Suhas
Saravu, Kavitha
Godkhindi, Vishwapriya M
author_sort Vijayasekharan, Kalasekhar
collection PubMed
description Disseminated cryptococcosis in children is a classic affliction associated with human immunodeficiency virus (HIV) infection or primary inherited immunodeficiency disorders (PID) with central nervous system being the most common site of dissemination. We report a rare case of disseminated cryptococcosis in an 11-year-old girl who presented with pulmonary involvement, hepatosplenomegaly, and generalized lymphadenopathy. No known inherited or acquired immune deficiencies were identified after a comprehensive laboratory work-up including genetic sequencing. She responded well to anti-fungal therapy (flucytosine and amphotericin followed by fluconazole) and is on regular follow-up. 
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spelling pubmed-82458272021-07-07 Disseminated Cryptococcosis in an Immunocompetent Child Vijayasekharan, Kalasekhar Gupta, Nitin Reddisetti, Suhas Saravu, Kavitha Godkhindi, Vishwapriya M Cureus Pediatrics Disseminated cryptococcosis in children is a classic affliction associated with human immunodeficiency virus (HIV) infection or primary inherited immunodeficiency disorders (PID) with central nervous system being the most common site of dissemination. We report a rare case of disseminated cryptococcosis in an 11-year-old girl who presented with pulmonary involvement, hepatosplenomegaly, and generalized lymphadenopathy. No known inherited or acquired immune deficiencies were identified after a comprehensive laboratory work-up including genetic sequencing. She responded well to anti-fungal therapy (flucytosine and amphotericin followed by fluconazole) and is on regular follow-up.  Cureus 2021-05-31 /pmc/articles/PMC8245827/ /pubmed/34239794 http://dx.doi.org/10.7759/cureus.15362 Text en Copyright © 2021, Vijayasekharan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Vijayasekharan, Kalasekhar
Gupta, Nitin
Reddisetti, Suhas
Saravu, Kavitha
Godkhindi, Vishwapriya M
Disseminated Cryptococcosis in an Immunocompetent Child
title Disseminated Cryptococcosis in an Immunocompetent Child
title_full Disseminated Cryptococcosis in an Immunocompetent Child
title_fullStr Disseminated Cryptococcosis in an Immunocompetent Child
title_full_unstemmed Disseminated Cryptococcosis in an Immunocompetent Child
title_short Disseminated Cryptococcosis in an Immunocompetent Child
title_sort disseminated cryptococcosis in an immunocompetent child
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245827/
https://www.ncbi.nlm.nih.gov/pubmed/34239794
http://dx.doi.org/10.7759/cureus.15362
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