High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3

Neutrophil adhesion on the atheroprone femoral artery of high-fat diet–fed low-density lipoprotein receptor–null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullinat...

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Detalles Bibliográficos
Autores principales: Osaka, Mizuko, Deushi, Michiyo, Aoyama, Jiro, Funakoshi, Tomoko, Ishigami, Akihito, Yoshida, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246031/
https://www.ncbi.nlm.nih.gov/pubmed/34222722
http://dx.doi.org/10.1016/j.jacbts.2021.04.002
Descripción
Sumario:Neutrophil adhesion on the atheroprone femoral artery of high-fat diet–fed low-density lipoprotein receptor–null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullination contributes to enhanced neutrophil adhesion. Furthermore, pemafibrate reduced the citrullination of histone H3 in these mice. Therefore, the hypercitrullination of histone H3 in neutrophils contributes to atherosclerotic vascular inflammation.

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