High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3

Neutrophil adhesion on the atheroprone femoral artery of high-fat diet–fed low-density lipoprotein receptor–null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullinat...

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Autores principales: Osaka, Mizuko, Deushi, Michiyo, Aoyama, Jiro, Funakoshi, Tomoko, Ishigami, Akihito, Yoshida, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246031/
https://www.ncbi.nlm.nih.gov/pubmed/34222722
http://dx.doi.org/10.1016/j.jacbts.2021.04.002
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author Osaka, Mizuko
Deushi, Michiyo
Aoyama, Jiro
Funakoshi, Tomoko
Ishigami, Akihito
Yoshida, Masayuki
author_facet Osaka, Mizuko
Deushi, Michiyo
Aoyama, Jiro
Funakoshi, Tomoko
Ishigami, Akihito
Yoshida, Masayuki
author_sort Osaka, Mizuko
collection PubMed
description Neutrophil adhesion on the atheroprone femoral artery of high-fat diet–fed low-density lipoprotein receptor–null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullination contributes to enhanced neutrophil adhesion. Furthermore, pemafibrate reduced the citrullination of histone H3 in these mice. Therefore, the hypercitrullination of histone H3 in neutrophils contributes to atherosclerotic vascular inflammation.
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spelling pubmed-82460312021-07-02 High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3 Osaka, Mizuko Deushi, Michiyo Aoyama, Jiro Funakoshi, Tomoko Ishigami, Akihito Yoshida, Masayuki JACC Basic Transl Sci Preclinical Research Neutrophil adhesion on the atheroprone femoral artery of high-fat diet–fed low-density lipoprotein receptor–null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullination contributes to enhanced neutrophil adhesion. Furthermore, pemafibrate reduced the citrullination of histone H3 in these mice. Therefore, the hypercitrullination of histone H3 in neutrophils contributes to atherosclerotic vascular inflammation. Elsevier 2021-05-19 /pmc/articles/PMC8246031/ /pubmed/34222722 http://dx.doi.org/10.1016/j.jacbts.2021.04.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Osaka, Mizuko
Deushi, Michiyo
Aoyama, Jiro
Funakoshi, Tomoko
Ishigami, Akihito
Yoshida, Masayuki
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
title High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
title_full High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
title_fullStr High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
title_full_unstemmed High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
title_short High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
title_sort high-fat diet enhances neutrophil adhesion in ldlr-null mice via hypercitrullination of histone h3
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246031/
https://www.ncbi.nlm.nih.gov/pubmed/34222722
http://dx.doi.org/10.1016/j.jacbts.2021.04.002
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