Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination

The palladium-catalysed tandem aza-Heck–Suzuki and aza-Heck–carbonylation reactions of O-phenyl hydroxamic ethers are reported. These formal alkene carboamination reactions provide highly versatile access to wide range complex, stereogenic secondary lactams and exhibit outstanding functional group t...

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Detalles Bibliográficos
Autores principales: Gao, Run-Duo, Shuler, Scott A., Watson, Donald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246078/
https://www.ncbi.nlm.nih.gov/pubmed/34257886
http://dx.doi.org/10.1039/d1sc02075g
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author Gao, Run-Duo
Shuler, Scott A.
Watson, Donald A.
author_facet Gao, Run-Duo
Shuler, Scott A.
Watson, Donald A.
author_sort Gao, Run-Duo
collection PubMed
description The palladium-catalysed tandem aza-Heck–Suzuki and aza-Heck–carbonylation reactions of O-phenyl hydroxamic ethers are reported. These formal alkene carboamination reactions provide highly versatile access to wide range complex, stereogenic secondary lactams and exhibit outstanding functional group tolerance and high diastereoselectivity.
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spelling pubmed-82460782021-07-12 Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination Gao, Run-Duo Shuler, Scott A. Watson, Donald A. Chem Sci Chemistry The palladium-catalysed tandem aza-Heck–Suzuki and aza-Heck–carbonylation reactions of O-phenyl hydroxamic ethers are reported. These formal alkene carboamination reactions provide highly versatile access to wide range complex, stereogenic secondary lactams and exhibit outstanding functional group tolerance and high diastereoselectivity. The Royal Society of Chemistry 2021-05-27 /pmc/articles/PMC8246078/ /pubmed/34257886 http://dx.doi.org/10.1039/d1sc02075g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Gao, Run-Duo
Shuler, Scott A.
Watson, Donald A.
Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination
title Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination
title_full Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination
title_fullStr Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination
title_full_unstemmed Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination
title_short Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination
title_sort tandem aza-heck suzuki and carbonylation reactions of o-phenyl hydroxamic ethers: complex lactams via carboamination
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246078/
https://www.ncbi.nlm.nih.gov/pubmed/34257886
http://dx.doi.org/10.1039/d1sc02075g
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AT watsondonalda tandemazahecksuzukiandcarbonylationreactionsofophenylhydroxamicetherscomplexlactamsviacarboamination

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