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Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates
Long-range chirality recognition between the two chiral guest ligands can be tuned based on the helix distances (d(Ln–Ln) = 11.5 and 14.0 Å) of bis-diketonate bridged dinuclear lanthanide complexes (2Th and 3Th, respectively) used as mediators. Both 2Th and 3Th form one-dimensional (1D) helical stru...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246085/ https://www.ncbi.nlm.nih.gov/pubmed/34257874 http://dx.doi.org/10.1039/d1sc01611c |
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author | Suko, Natsumi Itamoto, Hideki Okayasu, Yoshinori Okura, Naoya Yuasa, Junpei |
author_facet | Suko, Natsumi Itamoto, Hideki Okayasu, Yoshinori Okura, Naoya Yuasa, Junpei |
author_sort | Suko, Natsumi |
collection | PubMed |
description | Long-range chirality recognition between the two chiral guest ligands can be tuned based on the helix distances (d(Ln–Ln) = 11.5 and 14.0 Å) of bis-diketonate bridged dinuclear lanthanide complexes (2Th and 3Th, respectively) used as mediators. Both 2Th and 3Th form one-dimensional (1D) helical structures upon terminal binding of two chiral guest co-ligands (L(R) or L(S)). Long-range chiral self-recognition is achieved in self-assembly of 2Th with L(R) and L(S) to preferentially form homochiral assemblies, 2Th-L(R)·L(R) and 2Th-L(S)·L(S), whereas there is no direct molecular interaction between the two guest ligands at the terminal edges. X-ray crystal structure analysis and density functional theory studies reveal that long-range chiral recognition is achieved by terminal ligand-to-ligand interactions between the bis-diketonate ligands and chiral guest co-ligands. Conversely, in self-assembly of 3Th with a longer helix length, statistical binding of L(R) and L(S) occurs, forming heterochiral (3Th-L(R)·L(S)) and homochiral (3Th-L(R)·L(R) and 3Th-L(S)·L(S)) assemblies in an almost 1 : 1 ratio. When phenyl side arms of the chiral guest co-ligands are replaced by isopropyl groups (L′(R) and L′(S)), chiral self-recognition is also achieved in the self-assembly process of 3Th with the longer helix length to generate homochiral (3Th-L′(R)·L′(R) and 3Th-L′(S)·L′(S)) assemblies as the favored products. Thus, subtle modification of the chiral guests is capable of achieving over 1.4 nm-range chirality recognition. |
format | Online Article Text |
id | pubmed-8246085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-82460852021-07-12 Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates Suko, Natsumi Itamoto, Hideki Okayasu, Yoshinori Okura, Naoya Yuasa, Junpei Chem Sci Chemistry Long-range chirality recognition between the two chiral guest ligands can be tuned based on the helix distances (d(Ln–Ln) = 11.5 and 14.0 Å) of bis-diketonate bridged dinuclear lanthanide complexes (2Th and 3Th, respectively) used as mediators. Both 2Th and 3Th form one-dimensional (1D) helical structures upon terminal binding of two chiral guest co-ligands (L(R) or L(S)). Long-range chiral self-recognition is achieved in self-assembly of 2Th with L(R) and L(S) to preferentially form homochiral assemblies, 2Th-L(R)·L(R) and 2Th-L(S)·L(S), whereas there is no direct molecular interaction between the two guest ligands at the terminal edges. X-ray crystal structure analysis and density functional theory studies reveal that long-range chiral recognition is achieved by terminal ligand-to-ligand interactions between the bis-diketonate ligands and chiral guest co-ligands. Conversely, in self-assembly of 3Th with a longer helix length, statistical binding of L(R) and L(S) occurs, forming heterochiral (3Th-L(R)·L(S)) and homochiral (3Th-L(R)·L(R) and 3Th-L(S)·L(S)) assemblies in an almost 1 : 1 ratio. When phenyl side arms of the chiral guest co-ligands are replaced by isopropyl groups (L′(R) and L′(S)), chiral self-recognition is also achieved in the self-assembly process of 3Th with the longer helix length to generate homochiral (3Th-L′(R)·L′(R) and 3Th-L′(S)·L′(S)) assemblies as the favored products. Thus, subtle modification of the chiral guests is capable of achieving over 1.4 nm-range chirality recognition. The Royal Society of Chemistry 2021-05-19 /pmc/articles/PMC8246085/ /pubmed/34257874 http://dx.doi.org/10.1039/d1sc01611c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Suko, Natsumi Itamoto, Hideki Okayasu, Yoshinori Okura, Naoya Yuasa, Junpei Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
title | Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
title_full | Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
title_fullStr | Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
title_full_unstemmed | Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
title_short | Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
title_sort | helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246085/ https://www.ncbi.nlm.nih.gov/pubmed/34257874 http://dx.doi.org/10.1039/d1sc01611c |
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