Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway

BACKGROUND: Andrographolide (Andro), a diterpenoid extracted from Andrographis paniculata, has been shown to attenuate pulmonary fibrosis in rodents; however, the potential mechanisms remain largely unclear. This study investigated whether and how Andro alleviates bleomycin (BLM)-induced NOD-like re...

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Detalles Bibliográficos
Autores principales: Li, Jingpei, Yang, Xiaohan, Yang, Penghui, Xu, Ke, Peng, Xiaomin, Cai, Weipeng, Zhao, Simin, Hu, Lei, Li, Zhuoyi, Cui, Fei, Wang, Wei, Peng, Guilin, Xu, Xin, He, Jianxing, Liu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246226/
https://www.ncbi.nlm.nih.gov/pubmed/34268377
http://dx.doi.org/10.21037/atm-20-7973

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