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Review of the potential of mesenchymal stem cells for the treatment of infectious diseases
The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246252/ https://www.ncbi.nlm.nih.gov/pubmed/34249228 http://dx.doi.org/10.4252/wjsc.v13.i6.568 |
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author | Sharma, Amit Chakraborty, Anuja Jaganathan, Bithiah Grace |
author_facet | Sharma, Amit Chakraborty, Anuja Jaganathan, Bithiah Grace |
author_sort | Sharma, Amit |
collection | PubMed |
description | The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretion of antimicrobial factors for pathogen clearance and they phagocytose certain bacteria themselves. MSCs dampen tissue damage during infection by downregulating the levels of pro-inflammatory cytokines, and inhibiting the excessive recruitment of neutrophils and proliferation of T cells at the site of injury. MSCs aid in the regeneration of damaged tissue by differentiating into the damaged cell types or by releasing paracrine factors that direct tissue regeneration, differentiation, and wound healing. In this review, we discuss in detail the various mechanisms by which MSCs help combat pathogens, tissue damage associated with infectious diseases, and challenges in utilizing MSCs for therapy. |
format | Online Article Text |
id | pubmed-8246252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-82462522021-07-08 Review of the potential of mesenchymal stem cells for the treatment of infectious diseases Sharma, Amit Chakraborty, Anuja Jaganathan, Bithiah Grace World J Stem Cells Review The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretion of antimicrobial factors for pathogen clearance and they phagocytose certain bacteria themselves. MSCs dampen tissue damage during infection by downregulating the levels of pro-inflammatory cytokines, and inhibiting the excessive recruitment of neutrophils and proliferation of T cells at the site of injury. MSCs aid in the regeneration of damaged tissue by differentiating into the damaged cell types or by releasing paracrine factors that direct tissue regeneration, differentiation, and wound healing. In this review, we discuss in detail the various mechanisms by which MSCs help combat pathogens, tissue damage associated with infectious diseases, and challenges in utilizing MSCs for therapy. Baishideng Publishing Group Inc 2021-06-26 2021-06-26 /pmc/articles/PMC8246252/ /pubmed/34249228 http://dx.doi.org/10.4252/wjsc.v13.i6.568 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Sharma, Amit Chakraborty, Anuja Jaganathan, Bithiah Grace Review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
title | Review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
title_full | Review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
title_fullStr | Review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
title_full_unstemmed | Review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
title_short | Review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
title_sort | review of the potential of mesenchymal stem cells for the treatment of infectious diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246252/ https://www.ncbi.nlm.nih.gov/pubmed/34249228 http://dx.doi.org/10.4252/wjsc.v13.i6.568 |
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