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Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study

Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and gen...

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Autores principales: Springer, Adrian, Schleberger, Ruben, Oyen, Florian, Hoffmann, Boris A., Willems, Stephan, Meyer, Christian, Langer, Florian, Schnabel, Renate B., Kirchhof, Paulus, Schneppenheim, Reinhard, Lemoine, Marc D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246465/
https://www.ncbi.nlm.nih.gov/pubmed/34184557
http://dx.doi.org/10.1177/10760296211021171
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author Springer, Adrian
Schleberger, Ruben
Oyen, Florian
Hoffmann, Boris A.
Willems, Stephan
Meyer, Christian
Langer, Florian
Schnabel, Renate B.
Kirchhof, Paulus
Schneppenheim, Reinhard
Lemoine, Marc D.
author_facet Springer, Adrian
Schleberger, Ruben
Oyen, Florian
Hoffmann, Boris A.
Willems, Stephan
Meyer, Christian
Langer, Florian
Schnabel, Renate B.
Kirchhof, Paulus
Schneppenheim, Reinhard
Lemoine, Marc D.
author_sort Springer, Adrian
collection PubMed
description Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA(2)DS(2)-VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients.
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spelling pubmed-82464652021-07-13 Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study Springer, Adrian Schleberger, Ruben Oyen, Florian Hoffmann, Boris A. Willems, Stephan Meyer, Christian Langer, Florian Schnabel, Renate B. Kirchhof, Paulus Schneppenheim, Reinhard Lemoine, Marc D. Clin Appl Thromb Hemost Original Manuscript Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA(2)DS(2)-VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients. SAGE Publications 2021-06-29 /pmc/articles/PMC8246465/ /pubmed/34184557 http://dx.doi.org/10.1177/10760296211021171 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
Springer, Adrian
Schleberger, Ruben
Oyen, Florian
Hoffmann, Boris A.
Willems, Stephan
Meyer, Christian
Langer, Florian
Schnabel, Renate B.
Kirchhof, Paulus
Schneppenheim, Reinhard
Lemoine, Marc D.
Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
title Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
title_full Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
title_fullStr Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
title_full_unstemmed Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
title_short Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
title_sort genetic and clinical predictors of left atrial thrombus: a single center case-control study
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246465/
https://www.ncbi.nlm.nih.gov/pubmed/34184557
http://dx.doi.org/10.1177/10760296211021171
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