Cargando…

Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm

Individuals born very preterm (<32 weeks gestation) have altered brain growth and white matter maturation relative to their full-term peers, and approximately 30% will experience neurodevelopmental impairment. We investigated the relationship between neurodevelopmental impairment and MRI measures...

Descripción completa

Detalles Bibliográficos
Autores principales: Kennedy, Eleanor, Poppe, Tanya, Tottman, Anna, Harding, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246637/
https://www.ncbi.nlm.nih.gov/pubmed/34174689
http://dx.doi.org/10.1016/j.nicl.2021.102730
_version_ 1783716351848742912
author Kennedy, Eleanor
Poppe, Tanya
Tottman, Anna
Harding, Jane
author_facet Kennedy, Eleanor
Poppe, Tanya
Tottman, Anna
Harding, Jane
author_sort Kennedy, Eleanor
collection PubMed
description Individuals born very preterm (<32 weeks gestation) have altered brain growth and white matter maturation relative to their full-term peers, and approximately 30% will experience neurodevelopmental impairment. We investigated the relationship between neurodevelopmental impairment and MRI measures of white matter microstructure and brain volume. Children born before 30 weeks’ gestation or who had very low birthweight (< 1500 g) underwent neurodevelopmental assessment and MRI at age 7 years as part of the PIANO study, a New Zealand-based cohort study. Fractional anisotropy (FA) and diffusivity measures were derived from diffusion tensor imaging to index white matter microstructure. Volumes were derived from T1-weighted imaging. Neurodevelopmental impairment was defined as a score < 85 on the Wechsler Intelligence Scale for Children, <5th centile on the Movement Assessment Battery for Children or a diagnosis of cerebral palsy by a paediatrician. Relationships between MRI and neurodevelopmental impairment were assessed with general linear models adjusted for sex, gestational age at birth, birthweight z-score, age at assessment, New Zealand Deprivation index score and multiplicity. Children with neurodevelopmental impairment (n = 38) had smaller total brain, cortical grey matter and cerebral white matter volumes compared to children without neurodevelopmental impairment (n = 62) (p < 0.05, false discovery rate corrected), but the regional volume differences did not remain significant after adjustment for total brain volume. Lower FA and higher radial diffusivity were observed in the superior longitudinal fasciculi, uncinate fasciculi and right hemisphere corticospinal tract in children with neurodevelopmental impairment. This may reflect differences in cellular properties such as myelination or axonal packing. Neurodevelopmental impairment may reflect smaller overall brain volume and altered microstructure in white matter tracts that are important for language, cognitive and motor functioning.
format Online
Article
Text
id pubmed-8246637
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-82466372021-07-06 Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm Kennedy, Eleanor Poppe, Tanya Tottman, Anna Harding, Jane Neuroimage Clin Regular Article Individuals born very preterm (<32 weeks gestation) have altered brain growth and white matter maturation relative to their full-term peers, and approximately 30% will experience neurodevelopmental impairment. We investigated the relationship between neurodevelopmental impairment and MRI measures of white matter microstructure and brain volume. Children born before 30 weeks’ gestation or who had very low birthweight (< 1500 g) underwent neurodevelopmental assessment and MRI at age 7 years as part of the PIANO study, a New Zealand-based cohort study. Fractional anisotropy (FA) and diffusivity measures were derived from diffusion tensor imaging to index white matter microstructure. Volumes were derived from T1-weighted imaging. Neurodevelopmental impairment was defined as a score < 85 on the Wechsler Intelligence Scale for Children, <5th centile on the Movement Assessment Battery for Children or a diagnosis of cerebral palsy by a paediatrician. Relationships between MRI and neurodevelopmental impairment were assessed with general linear models adjusted for sex, gestational age at birth, birthweight z-score, age at assessment, New Zealand Deprivation index score and multiplicity. Children with neurodevelopmental impairment (n = 38) had smaller total brain, cortical grey matter and cerebral white matter volumes compared to children without neurodevelopmental impairment (n = 62) (p < 0.05, false discovery rate corrected), but the regional volume differences did not remain significant after adjustment for total brain volume. Lower FA and higher radial diffusivity were observed in the superior longitudinal fasciculi, uncinate fasciculi and right hemisphere corticospinal tract in children with neurodevelopmental impairment. This may reflect differences in cellular properties such as myelination or axonal packing. Neurodevelopmental impairment may reflect smaller overall brain volume and altered microstructure in white matter tracts that are important for language, cognitive and motor functioning. Elsevier 2021-06-17 /pmc/articles/PMC8246637/ /pubmed/34174689 http://dx.doi.org/10.1016/j.nicl.2021.102730 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Kennedy, Eleanor
Poppe, Tanya
Tottman, Anna
Harding, Jane
Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
title Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
title_full Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
title_fullStr Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
title_full_unstemmed Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
title_short Neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
title_sort neurodevelopmental impairment is associated with altered white matter development in a cohort of school-aged children born very preterm
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246637/
https://www.ncbi.nlm.nih.gov/pubmed/34174689
http://dx.doi.org/10.1016/j.nicl.2021.102730
work_keys_str_mv AT kennedyeleanor neurodevelopmentalimpairmentisassociatedwithalteredwhitematterdevelopmentinacohortofschoolagedchildrenbornverypreterm
AT poppetanya neurodevelopmentalimpairmentisassociatedwithalteredwhitematterdevelopmentinacohortofschoolagedchildrenbornverypreterm
AT tottmananna neurodevelopmentalimpairmentisassociatedwithalteredwhitematterdevelopmentinacohortofschoolagedchildrenbornverypreterm
AT hardingjane neurodevelopmentalimpairmentisassociatedwithalteredwhitematterdevelopmentinacohortofschoolagedchildrenbornverypreterm