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Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physi...

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Autores principales: Rajagopal, Gopalan, Nivetha, Ambikapathi, Sundar, Madasamy, Panneerselvam, Theivendran, Murugesan, Sankaranarayanan, Parasuraman, Pavadai, Kumar, Sattanathan, Ilango, Sakkanan, Kunjiappan, Selvaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246643/
https://www.ncbi.nlm.nih.gov/pubmed/34235284
http://dx.doi.org/10.1016/j.heliyon.2021.e07360
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author Rajagopal, Gopalan
Nivetha, Ambikapathi
Sundar, Madasamy
Panneerselvam, Theivendran
Murugesan, Sankaranarayanan
Parasuraman, Pavadai
Kumar, Sattanathan
Ilango, Sakkanan
Kunjiappan, Selvaraj
author_facet Rajagopal, Gopalan
Nivetha, Ambikapathi
Sundar, Madasamy
Panneerselvam, Theivendran
Murugesan, Sankaranarayanan
Parasuraman, Pavadai
Kumar, Sattanathan
Ilango, Sakkanan
Kunjiappan, Selvaraj
author_sort Rajagopal, Gopalan
collection PubMed
description The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physicochemical properties of Wt extract mediated synthesized CuNPs (Wt-CuNPs). The Wt-CuNPs synthesized was found to be monodispersed and spherical, with an average size of 15 nm. Gas chromatography and mass spectrometry (GC-MS) research revealed that the Wt R.Br plant extract contains various phytochemical compounds. The properties of Wt-CuNPs were verified by the findings of characterization tests. Via in silico molecular docking experiments with established targets, the underlying mechanisms of cytotoxicity against breast cancer and larvicidal behaviour against Aedes aegypti of Wt-CuNPs were investigated. Interestingly, in vitro cytotoxicity studies showed 50% cell death (IC(50)) of Wt-CuNPs treated MCF-7 cells and Vero Cells (Kidney epithelial cells) were displayed at 119.23 μg.mL(−1) and 898.75 μg.mL(−1), respectively. Also, Wt-CuNPs showed least LC(50) and LC(90) values for larvicidal activity against A. aegypti were of 32.10 μg.mL(−1) and 21.70 μg.mL(−1), respectively. Furthermore, Wt-CuNPs is found to be less toxic and biocompatible in haemolytic assays. The findings clearly showed that biosynthesized Wt-CuNPs have been used as a possible anticancer and larvicidal agent, as well as being environmentally friendly.
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spelling pubmed-82466432021-07-06 Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications Rajagopal, Gopalan Nivetha, Ambikapathi Sundar, Madasamy Panneerselvam, Theivendran Murugesan, Sankaranarayanan Parasuraman, Pavadai Kumar, Sattanathan Ilango, Sakkanan Kunjiappan, Selvaraj Heliyon Research Article The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physicochemical properties of Wt extract mediated synthesized CuNPs (Wt-CuNPs). The Wt-CuNPs synthesized was found to be monodispersed and spherical, with an average size of 15 nm. Gas chromatography and mass spectrometry (GC-MS) research revealed that the Wt R.Br plant extract contains various phytochemical compounds. The properties of Wt-CuNPs were verified by the findings of characterization tests. Via in silico molecular docking experiments with established targets, the underlying mechanisms of cytotoxicity against breast cancer and larvicidal behaviour against Aedes aegypti of Wt-CuNPs were investigated. Interestingly, in vitro cytotoxicity studies showed 50% cell death (IC(50)) of Wt-CuNPs treated MCF-7 cells and Vero Cells (Kidney epithelial cells) were displayed at 119.23 μg.mL(−1) and 898.75 μg.mL(−1), respectively. Also, Wt-CuNPs showed least LC(50) and LC(90) values for larvicidal activity against A. aegypti were of 32.10 μg.mL(−1) and 21.70 μg.mL(−1), respectively. Furthermore, Wt-CuNPs is found to be less toxic and biocompatible in haemolytic assays. The findings clearly showed that biosynthesized Wt-CuNPs have been used as a possible anticancer and larvicidal agent, as well as being environmentally friendly. Elsevier 2021-06-22 /pmc/articles/PMC8246643/ /pubmed/34235284 http://dx.doi.org/10.1016/j.heliyon.2021.e07360 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Rajagopal, Gopalan
Nivetha, Ambikapathi
Sundar, Madasamy
Panneerselvam, Theivendran
Murugesan, Sankaranarayanan
Parasuraman, Pavadai
Kumar, Sattanathan
Ilango, Sakkanan
Kunjiappan, Selvaraj
Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
title Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
title_full Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
title_fullStr Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
title_full_unstemmed Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
title_short Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
title_sort mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246643/
https://www.ncbi.nlm.nih.gov/pubmed/34235284
http://dx.doi.org/10.1016/j.heliyon.2021.e07360
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