Cargando…

Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT

BACKGROUND: Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1 (APE1) promotes tumor metastasis and is overexpressed in cervical cancer. However, the biological role and mechanism of APE1 in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qing, Zhou, Zhi-Wei, Duan, Wei, Qian, Cheng-Yuan, Wang, Shu-Nan, Deng, Meng-Sheng, Zi, Dan, Wang, Jian-Min, Mao, Cheng-Yi, Song, Guanbin, Wang, Dong, Westover, Kenneth D., Xu, Cheng-Xiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246661/ https://www.ncbi.nlm.nih.gov/pubmed/34210327 http://dx.doi.org/10.1186/s13046-021-02006-5

Ejemplares similares

GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level
por: Li, Qing, et al.
Publicado: (2018)

CBX6 Promotes HCC Metastasis Via Transcription Factors Snail/Zeb1-Mediated EMT Mechanism
por: Wang, Jiamu, et al.
Publicado: (2020)

The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas
por: Sánchez-Tilló, Ester, et al.
Publicado: (2023)

An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer
por: Qin, Yong, et al.
Publicado: (2015)

Comparison of Snail1, ZEB1, E-Cadherin Expression Levels in HPV-Induced Cervical Cancer
por: FARZANEHPOUR, Mahdieh, et al.
Publicado: (2020)

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors
por: Mock, Kerstin, et al.
Publicado: (2015)

An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes
por: Zhong, Canrong, et al.
Publicado: (2017)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2018)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2021)

miRNA-199b-3p suppresses growth and progression of ovarian cancer via the CHK1/E-cadherin/EMT signaling pathway by targeting ZEB1
por: Wei, Liqun, et al.
Publicado: (2021)

ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma
por: Zheng, Yayuan, et al.
Publicado: (2022)

NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression
por: Faiola, Francesco, et al.
Publicado: (2017)

ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1
por: Liu, D, et al.
Publicado: (2018)

Cordycepin Inhibits Triple-Negative Breast Cancer Cell Migration and Invasion by Regulating EMT-TFs SLUG, TWIST1, SNAIL1, and ZEB1
por: Wei, Chunli, et al.
Publicado: (2022)

PTTG1/ZEB1 Axis Regulates E-Cadherin Expression in Human Seminoma
por: Teveroni, Emanuela, et al.
Publicado: (2022)

Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis
por: Mohammadi Ghahhari, Nastaran, et al.
Publicado: (2022)

ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis
por: Perez-Oquendo, Mabel, et al.
Publicado: (2023)

Long non-coding RNA ZEB1-AS1 promotes cell invasion and epithelial to mesenchymal transition through inducing ZEB1 expression in cervical cancer
por: Cheng, Rongjie, et al.
Publicado: (2018)

APE1 stimulates EGFR-TKI resistance by activating Akt signaling through a redox-dependent mechanism in lung adenocarcinoma
por: Lu, Guo-Shou, et al.
Publicado: (2018)

Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC)
por: Hashiguchi, Motoyuki, et al.
Publicado: (2013)

ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC
por: Lazarova, Darina, et al.
Publicado: (2017)

Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer
por: Wu, Hua-Tao, et al.
Publicado: (2020)

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity
por: Wang, Jueqiong, et al.
Publicado: (2021)

lncRNA ZEB1-AS1 promotes migration and metastasis of bladder cancer cells by post-transcriptional activation of ZEB1
por: Zhao, Xin, et al.
Publicado: (2019)

Doxycycline inhibits breast cancer EMT and metastasis through PAR-1/NF-κB/miR-17/E-cadherin pathway
por: Zhong, Weilong, et al.
Publicado: (2017)

Overexpression of ZEB2‐AS1 promotes epithelial‐to‐mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma
por: Diao, Pengfei, et al.
Publicado: (2019)

Prognostic significance of E-cadherin and ZEB1 expression in intraductal papillary mucinous neoplasm
por: Chang, Ye Rim, et al.
Publicado: (2017)

EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells
por: Lindner, Pablo, et al.
Publicado: (2020)

The microRNA-708-5p/ZEB1/EMT axis mediates the metastatic potential of osteosarcoma
por: Feng, Tianyu, et al.
Publicado: (2020)

EMT induced by loss of LKB1 promotes migration and invasion of liver cancer cells through ZEB1-induced YAP signaling
por: Qiu, Bijun, et al.
Publicado: (2018)

Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression
por: Nassour, Hassan, et al.
Publicado: (2016)

Genome‐wide cooperation of EMT transcription factor ZEB1 with YAP and AP‐1 in breast cancer
por: Feldker, Nora, et al.
Publicado: (2020)

Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT
por: Rogers, Crystal D., et al.
Publicado: (2013)

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis
por: Ming, He, et al.
Publicado: (2018)

Prognostic Role of Epithelial-Mesenchymal Transition Markers “E-Cadherin, β-Catenin, ZEB1, ZEB2 and p63” in Bladder Carcinoma
por: Moussa, Rabab Ahmed, et al.
Publicado: (2019)

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
por: Manshouri, Roxsan, et al.
Publicado: (2019)

Aberrant expression of redox protein Ape1 in colon cancer stem cells
por: LOU, DEBAO, et al.
Publicado: (2014)

miR-655 Is an EMT-Suppressive MicroRNA Targeting ZEB1 and TGFBR2
por: Harazono, Yosuke, et al.
Publicado: (2013)

The EMT-activator ZEB1 is unrelated to platinum drug resistance in ovarian cancer but is predictive of survival
por: Rae, Sophie, et al.
Publicado: (2022)

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling
por: Sheng, Weiwei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m352guc6nj9219115pl6i9ulp7