Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers

Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs indepe...

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Detalles Bibliográficos
Autores principales: Isnard, Stephane, Ramendra, Rayoun, Lin, John, Kant, Sanket, Fombuena, Brandon, Ouyang, Jing, Peng, Xiaorong, El Far, Mohamed, Tremblay, Cécile, Bernard, Nicole F, Routy, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246824/
https://www.ncbi.nlm.nih.gov/pubmed/32756974
http://dx.doi.org/10.1093/cid/ciaa1129
Descripción
Sumario:Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs independently of age, sex, and human leukocyte antigen (HLA) type. Elevated anti-CMV titers may favor disease progression in ECs.

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