Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers

Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs indepe...

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Autores principales: Isnard, Stephane, Ramendra, Rayoun, Lin, John, Kant, Sanket, Fombuena, Brandon, Ouyang, Jing, Peng, Xiaorong, El Far, Mohamed, Tremblay, Cécile, Bernard, Nicole F, Routy, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246824/
https://www.ncbi.nlm.nih.gov/pubmed/32756974
http://dx.doi.org/10.1093/cid/ciaa1129
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author Isnard, Stephane
Ramendra, Rayoun
Lin, John
Kant, Sanket
Fombuena, Brandon
Ouyang, Jing
Peng, Xiaorong
El Far, Mohamed
Tremblay, Cécile
Bernard, Nicole F
Routy, Jean-Pierre
author_facet Isnard, Stephane
Ramendra, Rayoun
Lin, John
Kant, Sanket
Fombuena, Brandon
Ouyang, Jing
Peng, Xiaorong
El Far, Mohamed
Tremblay, Cécile
Bernard, Nicole F
Routy, Jean-Pierre
author_sort Isnard, Stephane
collection PubMed
description Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs independently of age, sex, and human leukocyte antigen (HLA) type. Elevated anti-CMV titers may favor disease progression in ECs.
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spelling pubmed-82468242021-07-02 Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers Isnard, Stephane Ramendra, Rayoun Lin, John Kant, Sanket Fombuena, Brandon Ouyang, Jing Peng, Xiaorong El Far, Mohamed Tremblay, Cécile Bernard, Nicole F Routy, Jean-Pierre Clin Infect Dis Brief Reports Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs independently of age, sex, and human leukocyte antigen (HLA) type. Elevated anti-CMV titers may favor disease progression in ECs. Oxford University Press 2020-08-05 /pmc/articles/PMC8246824/ /pubmed/32756974 http://dx.doi.org/10.1093/cid/ciaa1129 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Isnard, Stephane
Ramendra, Rayoun
Lin, John
Kant, Sanket
Fombuena, Brandon
Ouyang, Jing
Peng, Xiaorong
El Far, Mohamed
Tremblay, Cécile
Bernard, Nicole F
Routy, Jean-Pierre
Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers
title Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers
title_full Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers
title_fullStr Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers
title_full_unstemmed Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers
title_short Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers
title_sort anti-cytomegalovirus immunoglobulin g is linked to cd4 t-cell count decay in human immunodeficiency virus (hiv) elite controllers
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246824/
https://www.ncbi.nlm.nih.gov/pubmed/32756974
http://dx.doi.org/10.1093/cid/ciaa1129
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