Cargando…

The nociceptin/orphanin FQ receptor system as a target to alleviate cancer‐induced bone pain in rats: Model validation and pharmacological evaluation

BACKGROUND AND PURPOSE: Cancer‐induced bone pain remains inadequately controlled, and current standard of care analgesics is accompanied by several side effects. Nociceptin/orphanin FQ peptide (NOP) receptor agonists have demonstrated broad analgesic properties in rodent neuropathic and inflammatory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sliepen, Sonny H.J., Korioth, Johanna, Christoph, Thomas, Tzschentke, Thomas M., Diaz‐delCastillo, Marta, Heegaard, Anne‐Marie, Rutten, Kris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	The Molecular Pharmacology of Bone and Cancer‐related Bone Diseases–Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246843/ https://www.ncbi.nlm.nih.gov/pubmed/31724155 http://dx.doi.org/10.1111/bph.14899

Ejemplares similares

Regulating and regulated role of the orphanin FQ/nociceptin system
por: Tekes, Kornélia, et al.
Publicado: (2009)

Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain
por: El Daibani, Amal, et al.
Publicado: (2022)

Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic
por: Thompson, Aaron A., et al.
Publicado: (2012)

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2014)

The role of orphanin FQ/nociceptin in neuroplasticity: relationship to stress, anxiety and neuroinflammation
por: Mallimo, Elyse M., et al.
Publicado: (2013)

Expression of the nociceptin/orphanin FQ receptor in the intestinal mucosa of IBS patients
por: LI, LU, et al.
Publicado: (2013)

IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism
por: Zingale, Gabriele Antonio, et al.
Publicado: (2019)

Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2
por: Malfacini, D., et al.
Publicado: (2015)

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands
por: Pacifico, Salvatore, et al.
Publicado: (2017)

Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System
por: Driscoll, Joseph R., et al.
Publicado: (2020)

Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists
por: Park, Jong Yung, et al.
Publicado: (2019)

Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity
por: Morairty, Stephen R., et al.
Publicado: (2023)

Structural Requirements of N-Substituted Spiropiperidine Analogues as Agonists of Nociceptin/Orphanin FQ Receptor
por: Bao, Pingping, et al.
Publicado: (2011)

Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD
por: Zhang, Yong, et al.
Publicado: (2012)

Nociceptin/Orphanin Fq in inflammation and remodeling of the small airways in experimental model of airway hyperresponsiveness
por: Tartaglione, Gioia, et al.
Publicado: (2018)

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders
por: Ubaldi, Massimo, et al.
Publicado: (2021)

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist
por: Rizzi, Anna, et al.
Publicado: (2016)

Nutritional state influences Nociceptin/Orphanin FQ peptide receptor expression in the dorsal raphe nucleus
por: Przydzial, Magdalena J., et al.
Publicado: (2009)

Role of Nociceptin/Orphanin FQ and NOP Receptors in the Response to Acute and Repeated Restraint Stress in Rats
por: Delaney, G, et al.
Publicado: (2012)

The Nociceptin/Orphanin FQ System Is Modulated in Patients Admitted to ICU with Sepsis and after Cardiopulmonary Bypass
por: Thompson, Jonathan P., et al.
Publicado: (2013)

The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo
por: Brookes, Zoë L. S., et al.
Publicado: (2013)

Effects of Co-Administration of Intrathecal Nociceptin/Orphanin FQ and Opioid Antagonists on Formalin-Induced Pain in Rats
por: Lee, Heeseung
Publicado: (2013)

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects
por: Raffaele, Marco, et al.
Publicado: (2021)

A novel bioassay to detect Nociceptin/Orphanin FQ release from single human polymorphonuclear cells
por: Bird, M. F., et al.
Publicado: (2022)

Endogenous Nociceptin / Orphanin FQ System Involvement in Hypothalamic-Pituitary-Adrenal Axis Responses: Relevance to Models of Inflammation
por: Leggett, J D, et al.
Publicado: (2009)

Plasma concentrations of nociceptin/orphanin FQ: comparison of levels after general and neuraxial anesthesia for arthroscopic knee surgery
por: Lee, Heeseung, et al.
Publicado: (2013)

Nociceptin/Orphanin FQ Opioid Peptide-Receptor Expression in the Endometriosis-Associated Nerve Fibers—Possible Treatment Option?
por: Guan, Qihui, et al.
Publicado: (2023)

Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model
por: Christoph, Thomas, et al.
Publicado: (2018)

Blockade of nociceptin/orphanin FQ signaling facilitates an active copying strategy due to acute and repeated stressful stimuli in mice
por: Holanda, Victor A.D., et al.
Publicado: (2020)

Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats
por: Caputi, Francesca Felicia, et al.
Publicado: (2021)

Buprenorphine reduces methamphetamine intake and drug seeking behavior via activating nociceptin/orphanin FQ peptide receptor in rats
por: Wang, Fangmin, et al.
Publicado: (2022)

The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models
por: Aziz, Abdul Maruf Asif, et al.
Publicado: (2016)

Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor
por: Bird, M F, et al.
Publicado: (2018)

Nociceptin/Orphanin-FQ Inhibits Gonadotropin-Releasing Hormone Neurons via G-Protein-Gated Inwardly Rectifying Potassium Channels
por: Constantin, Stephanie, et al.
Publicado: (2018)

Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1–13)-NH(2)
por: Pacifico, Salvatore, et al.
Publicado: (2020)

In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells
por: Bird, Mark F., et al.
Publicado: (2022)

Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness
por: Mirra, Davida, et al.
Publicado: (2022)

Behavioral Responses and Expression of Nociceptin/Orphanin FQ and Its Receptor (N/OFQ-NOP System) during Experimental Tooth Movement in Rats
por: Liao, Zhengyu, et al.
Publicado: (2021)

Sex Differences in Nociceptin/Orphanin FQ Peptide Receptor-Mediated Pain and Anxiety Symptoms in a Preclinical Model of Post-traumatic Stress Disorder
por: Zhang, Yong, et al.
Publicado: (2019)

The Nociceptin/Orphanin FQ peptide receptor antagonist, SB-612111, improves cerebral blood flow in a rat model of traumatic brain injury
por: Al Yacoub, Omar N., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_857mkfukp2qqs4kfnodehmn6v4