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Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies

Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor c...

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Detalles Bibliográficos
Autores principales: Lyu, Tianxin, Zhang, Binglei, Li, Mengjia, Jiao, Xueli, Song, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246925/
https://www.ncbi.nlm.nih.gov/pubmed/32869900
http://dx.doi.org/10.1002/hon.2793
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author Lyu, Tianxin
Zhang, Binglei
Li, Mengjia
Jiao, Xueli
Song, Yongping
author_facet Lyu, Tianxin
Zhang, Binglei
Li, Mengjia
Jiao, Xueli
Song, Yongping
author_sort Lyu, Tianxin
collection PubMed
description Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types.
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spelling pubmed-82469252021-07-02 Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies Lyu, Tianxin Zhang, Binglei Li, Mengjia Jiao, Xueli Song, Yongping Hematol Oncol Reviews Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types. John Wiley and Sons Inc. 2020-09-01 2021-04 /pmc/articles/PMC8246925/ /pubmed/32869900 http://dx.doi.org/10.1002/hon.2793 Text en © 2020 The Authors. Hematological Oncology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Lyu, Tianxin
Zhang, Binglei
Li, Mengjia
Jiao, Xueli
Song, Yongping
Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
title Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
title_full Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
title_fullStr Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
title_full_unstemmed Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
title_short Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
title_sort research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246925/
https://www.ncbi.nlm.nih.gov/pubmed/32869900
http://dx.doi.org/10.1002/hon.2793
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