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Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies
Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246925/ https://www.ncbi.nlm.nih.gov/pubmed/32869900 http://dx.doi.org/10.1002/hon.2793 |
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author | Lyu, Tianxin Zhang, Binglei Li, Mengjia Jiao, Xueli Song, Yongping |
author_facet | Lyu, Tianxin Zhang, Binglei Li, Mengjia Jiao, Xueli Song, Yongping |
author_sort | Lyu, Tianxin |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types. |
format | Online Article Text |
id | pubmed-8246925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82469252021-07-02 Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies Lyu, Tianxin Zhang, Binglei Li, Mengjia Jiao, Xueli Song, Yongping Hematol Oncol Reviews Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self‐renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types. John Wiley and Sons Inc. 2020-09-01 2021-04 /pmc/articles/PMC8246925/ /pubmed/32869900 http://dx.doi.org/10.1002/hon.2793 Text en © 2020 The Authors. Hematological Oncology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Lyu, Tianxin Zhang, Binglei Li, Mengjia Jiao, Xueli Song, Yongping Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
title | Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
title_full | Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
title_fullStr | Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
title_full_unstemmed | Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
title_short | Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
title_sort | research progress on exosomes derived from mesenchymal stem cells in hematological malignancies |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246925/ https://www.ncbi.nlm.nih.gov/pubmed/32869900 http://dx.doi.org/10.1002/hon.2793 |
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