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Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort

INTRODUCTION: Hypertension predisposes to atrial fibrillation (AF) – a major risk factor for ischaemic stroke. Since a high dietary salt consumption is associated with hypertension, we investigated the association between urinary sodium excretion as a marker for dietary sodium intake and risk of new...

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Autores principales: Wuopio, J., Orho‐Melander, M., Ärnlöv, J., Nowak, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246952/
https://www.ncbi.nlm.nih.gov/pubmed/33210391
http://dx.doi.org/10.1111/joim.13194
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author Wuopio, J.
Orho‐Melander, M.
Ärnlöv, J.
Nowak, C.
author_facet Wuopio, J.
Orho‐Melander, M.
Ärnlöv, J.
Nowak, C.
author_sort Wuopio, J.
collection PubMed
description INTRODUCTION: Hypertension predisposes to atrial fibrillation (AF) – a major risk factor for ischaemic stroke. Since a high dietary salt consumption is associated with hypertension, we investigated the association between urinary sodium excretion as a marker for dietary sodium intake and risk of new‐onset AF in community‐dwelling adults. METHOD: The UK Biobank includes 40‐ to 69‐year‐old British residents recruited 2006–2010. Participants were divided into sex‐specific quintiles according to 24‐hour sodium excretion estimated based on spot samples with the Kawasaki equation. We excluded participants with AF at baseline. Cox regression adjusted for cardiovascular risk factors was used to assess associations with risk of AF, using the third quintile as reference. RESULTS: A total of 257 545 women and 215 535 men were included. During up to 10 years' follow‐up, 2221 women and 3751 men were diagnosed with AF. There was a tendency for an increased risk of AF in the lowest and highest quintiles of estimated daily salt intake in both women and men. In the fully adjusted model, significant associations were seen amongst men in the lowest and highest quintiles of sodium excretion (hazard ratio, HR(Qv1), 1.20; 95% CI, 1.08–1.32, P < 0.001, and HR(Qv5) 1.15, 95% CI, 1.03–1.27, P = 0.011). CONCLUSION: We found evidence for a U‐shaped association between estimated daily salt intake and AF risk amongst men. A suggestive J‐shaped association in women was not statistically confirmed, but analyses were likely underpowered. Our results suggest that above a certain physiological minimum level progressively higher salt intake is associated with increasing risk of AF.
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spelling pubmed-82469522021-07-02 Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort Wuopio, J. Orho‐Melander, M. Ärnlöv, J. Nowak, C. J Intern Med Original Articles INTRODUCTION: Hypertension predisposes to atrial fibrillation (AF) – a major risk factor for ischaemic stroke. Since a high dietary salt consumption is associated with hypertension, we investigated the association between urinary sodium excretion as a marker for dietary sodium intake and risk of new‐onset AF in community‐dwelling adults. METHOD: The UK Biobank includes 40‐ to 69‐year‐old British residents recruited 2006–2010. Participants were divided into sex‐specific quintiles according to 24‐hour sodium excretion estimated based on spot samples with the Kawasaki equation. We excluded participants with AF at baseline. Cox regression adjusted for cardiovascular risk factors was used to assess associations with risk of AF, using the third quintile as reference. RESULTS: A total of 257 545 women and 215 535 men were included. During up to 10 years' follow‐up, 2221 women and 3751 men were diagnosed with AF. There was a tendency for an increased risk of AF in the lowest and highest quintiles of estimated daily salt intake in both women and men. In the fully adjusted model, significant associations were seen amongst men in the lowest and highest quintiles of sodium excretion (hazard ratio, HR(Qv1), 1.20; 95% CI, 1.08–1.32, P < 0.001, and HR(Qv5) 1.15, 95% CI, 1.03–1.27, P = 0.011). CONCLUSION: We found evidence for a U‐shaped association between estimated daily salt intake and AF risk amongst men. A suggestive J‐shaped association in women was not statistically confirmed, but analyses were likely underpowered. Our results suggest that above a certain physiological minimum level progressively higher salt intake is associated with increasing risk of AF. John Wiley and Sons Inc. 2020-11-19 2021-05 /pmc/articles/PMC8246952/ /pubmed/33210391 http://dx.doi.org/10.1111/joim.13194 Text en © 2020 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Wuopio, J.
Orho‐Melander, M.
Ärnlöv, J.
Nowak, C.
Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
title Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
title_full Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
title_fullStr Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
title_full_unstemmed Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
title_short Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
title_sort estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246952/
https://www.ncbi.nlm.nih.gov/pubmed/33210391
http://dx.doi.org/10.1111/joim.13194
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