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Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application

OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set‐up. METHODS: Formulation morphology was investigated...

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Autores principales: Pany, Astrid, Wohlgenannt, Marie, Klopprogge, Safoura, Wolzt, Michael, Heuser, Thomas, Kotisch, Harald, Valenta, Claudia, Klang, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246995/
https://www.ncbi.nlm.nih.gov/pubmed/33236374
http://dx.doi.org/10.1111/ics.12674
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author Pany, Astrid
Wohlgenannt, Marie
Klopprogge, Safoura
Wolzt, Michael
Heuser, Thomas
Kotisch, Harald
Valenta, Claudia
Klang, Victoria
author_facet Pany, Astrid
Wohlgenannt, Marie
Klopprogge, Safoura
Wolzt, Michael
Heuser, Thomas
Kotisch, Harald
Valenta, Claudia
Klang, Victoria
author_sort Pany, Astrid
collection PubMed
description OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set‐up. METHODS: Formulation morphology was investigated using cryo‐transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin‐pH‐Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels. RESULTS: Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations. CONCLUSION: Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP‐β‐CD.
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spelling pubmed-82469952021-07-02 Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application Pany, Astrid Wohlgenannt, Marie Klopprogge, Safoura Wolzt, Michael Heuser, Thomas Kotisch, Harald Valenta, Claudia Klang, Victoria Int J Cosmet Sci Research Communication OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set‐up. METHODS: Formulation morphology was investigated using cryo‐transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin‐pH‐Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels. RESULTS: Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations. CONCLUSION: Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP‐β‐CD. John Wiley and Sons Inc. 2021-01-03 2021-04 /pmc/articles/PMC8246995/ /pubmed/33236374 http://dx.doi.org/10.1111/ics.12674 Text en © 2020 The Authors. International Journal of Cosmetic Science published by John Wiley & Sons Ltd on behalf of Society of Cosmetic Scientists and Societe Francaise de Cosmetologie https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Communication
Pany, Astrid
Wohlgenannt, Marie
Klopprogge, Safoura
Wolzt, Michael
Heuser, Thomas
Kotisch, Harald
Valenta, Claudia
Klang, Victoria
Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
title Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
title_full Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
title_fullStr Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
title_full_unstemmed Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
title_short Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
title_sort effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246995/
https://www.ncbi.nlm.nih.gov/pubmed/33236374
http://dx.doi.org/10.1111/ics.12674
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