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Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application
OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set‐up. METHODS: Formulation morphology was investigated...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246995/ https://www.ncbi.nlm.nih.gov/pubmed/33236374 http://dx.doi.org/10.1111/ics.12674 |
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author | Pany, Astrid Wohlgenannt, Marie Klopprogge, Safoura Wolzt, Michael Heuser, Thomas Kotisch, Harald Valenta, Claudia Klang, Victoria |
author_facet | Pany, Astrid Wohlgenannt, Marie Klopprogge, Safoura Wolzt, Michael Heuser, Thomas Kotisch, Harald Valenta, Claudia Klang, Victoria |
author_sort | Pany, Astrid |
collection | PubMed |
description | OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set‐up. METHODS: Formulation morphology was investigated using cryo‐transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin‐pH‐Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels. RESULTS: Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations. CONCLUSION: Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP‐β‐CD. |
format | Online Article Text |
id | pubmed-8246995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82469952021-07-02 Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application Pany, Astrid Wohlgenannt, Marie Klopprogge, Safoura Wolzt, Michael Heuser, Thomas Kotisch, Harald Valenta, Claudia Klang, Victoria Int J Cosmet Sci Research Communication OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set‐up. METHODS: Formulation morphology was investigated using cryo‐transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin‐pH‐Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels. RESULTS: Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations. CONCLUSION: Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP‐β‐CD. John Wiley and Sons Inc. 2021-01-03 2021-04 /pmc/articles/PMC8246995/ /pubmed/33236374 http://dx.doi.org/10.1111/ics.12674 Text en © 2020 The Authors. International Journal of Cosmetic Science published by John Wiley & Sons Ltd on behalf of Society of Cosmetic Scientists and Societe Francaise de Cosmetologie https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Communication Pany, Astrid Wohlgenannt, Marie Klopprogge, Safoura Wolzt, Michael Heuser, Thomas Kotisch, Harald Valenta, Claudia Klang, Victoria Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
title | Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
title_full | Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
title_fullStr | Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
title_full_unstemmed | Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
title_short | Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
title_sort | effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application |
topic | Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246995/ https://www.ncbi.nlm.nih.gov/pubmed/33236374 http://dx.doi.org/10.1111/ics.12674 |
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