Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response

Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma coptidis, is reported to possess antiviral activity. Our previous study has shown that BBR alleviates coxsackievirus B3 (CVB3) replication in HeLa cells. However, the anti‐CVB3 activity of BBR is still unclear in vivo. In this study, we...

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Autores principales: Dai, Qian, He, Xiaomei, Yu, Hua, Bai, Ying, Jiang, Lu, Sheng, Halei, Peng, Jin, Wang, Maolin, Yu, Jiang, Zhang, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247049/
https://www.ncbi.nlm.nih.gov/pubmed/33336842
http://dx.doi.org/10.1002/jmv.26747
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author Dai, Qian
He, Xiaomei
Yu, Hua
Bai, Ying
Jiang, Lu
Sheng, Halei
Peng, Jin
Wang, Maolin
Yu, Jiang
Zhang, Kebin
author_facet Dai, Qian
He, Xiaomei
Yu, Hua
Bai, Ying
Jiang, Lu
Sheng, Halei
Peng, Jin
Wang, Maolin
Yu, Jiang
Zhang, Kebin
author_sort Dai, Qian
collection PubMed
description Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma coptidis, is reported to possess antiviral activity. Our previous study has shown that BBR alleviates coxsackievirus B3 (CVB3) replication in HeLa cells. However, the anti‐CVB3 activity of BBR is still unclear in vivo. In this study, we explored the effect of BBR on CVB3‐induced viral myocarditis in mice. These results demonstrated the beneficial effect of BBR on alleviating CVB3‐induced myocarditis in vivo, which sheds new light on the utility of BBR as a therapeutic strategy against CVB3‐induced viral myocarditis.
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spelling pubmed-82470492021-07-02 Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response Dai, Qian He, Xiaomei Yu, Hua Bai, Ying Jiang, Lu Sheng, Halei Peng, Jin Wang, Maolin Yu, Jiang Zhang, Kebin J Med Virol Research Articles Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma coptidis, is reported to possess antiviral activity. Our previous study has shown that BBR alleviates coxsackievirus B3 (CVB3) replication in HeLa cells. However, the anti‐CVB3 activity of BBR is still unclear in vivo. In this study, we explored the effect of BBR on CVB3‐induced viral myocarditis in mice. These results demonstrated the beneficial effect of BBR on alleviating CVB3‐induced myocarditis in vivo, which sheds new light on the utility of BBR as a therapeutic strategy against CVB3‐induced viral myocarditis. John Wiley and Sons Inc. 2020-12-29 2021-06 /pmc/articles/PMC8247049/ /pubmed/33336842 http://dx.doi.org/10.1002/jmv.26747 Text en © 2020 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Dai, Qian
He, Xiaomei
Yu, Hua
Bai, Ying
Jiang, Lu
Sheng, Halei
Peng, Jin
Wang, Maolin
Yu, Jiang
Zhang, Kebin
Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
title Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
title_full Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
title_fullStr Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
title_full_unstemmed Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
title_short Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
title_sort berberine impairs coxsackievirus b3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247049/
https://www.ncbi.nlm.nih.gov/pubmed/33336842
http://dx.doi.org/10.1002/jmv.26747
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