Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting t...

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Autores principales: Ortiz, Maria A., Mikhailova, Tatiana, Li, Xiang, Porter, Baylee A., Bah, Alaji, Kotula, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247114/
https://www.ncbi.nlm.nih.gov/pubmed/34193161
http://dx.doi.org/10.1186/s12964-021-00750-x
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author Ortiz, Maria A.
Mikhailova, Tatiana
Li, Xiang
Porter, Baylee A.
Bah, Alaji
Kotula, Leszek
author_facet Ortiz, Maria A.
Mikhailova, Tatiana
Li, Xiang
Porter, Baylee A.
Bah, Alaji
Kotula, Leszek
author_sort Ortiz, Maria A.
collection PubMed
description Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00750-x.
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spelling pubmed-82471142021-07-06 Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition Ortiz, Maria A. Mikhailova, Tatiana Li, Xiang Porter, Baylee A. Bah, Alaji Kotula, Leszek Cell Commun Signal Review Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00750-x. BioMed Central 2021-06-30 /pmc/articles/PMC8247114/ /pubmed/34193161 http://dx.doi.org/10.1186/s12964-021-00750-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ortiz, Maria A.
Mikhailova, Tatiana
Li, Xiang
Porter, Baylee A.
Bah, Alaji
Kotula, Leszek
Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
title Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
title_full Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
title_fullStr Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
title_full_unstemmed Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
title_short Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
title_sort src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247114/
https://www.ncbi.nlm.nih.gov/pubmed/34193161
http://dx.doi.org/10.1186/s12964-021-00750-x
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