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Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
Objectives: Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 (COVID-19), its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The asso...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247197/ https://www.ncbi.nlm.nih.gov/pubmed/34388589 http://dx.doi.org/10.1016/j.nut.2021.111408 |
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author | Bianconi, Vanessa Mannarino, Massimo R. Figorilli, Filippo Cosentini, Elena Batori, Giuseppe Marini, Ettore Lombardini, Rita Gargaro, Marco Fallarino, Francesca Scarponi, Anna Maria Sahebkar, Amirhossein Pirro, Matteo |
author_facet | Bianconi, Vanessa Mannarino, Massimo R. Figorilli, Filippo Cosentini, Elena Batori, Giuseppe Marini, Ettore Lombardini, Rita Gargaro, Marco Fallarino, Francesca Scarponi, Anna Maria Sahebkar, Amirhossein Pirro, Matteo |
author_sort | Bianconi, Vanessa |
collection | PubMed |
description | Objectives: Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 (COVID-19), its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The association between Vit-D and the composite endpoint of intensive care unit (ICU) admission/in-hospital death was explored using univariable and multivariable analyses. Also, serum Vit-D level in patients with COVID-19 was compared with that in age- and sex-balanced COVID-19-negative controls (i.e., 50 inpatients with sepsis). Results: Serum Vit-D level was comparable between patients with COVID-19 and COVID-19-negative inpatients with sepsis (P = 0.397). No significant differences were found in serum Vit-D level according to COVID-19 severity at the time of hospital admission (P = 0.299). Incidence rates of the composite endpoint of ICU admission/in-hospital death did not differ significantly between patients with either Vit-D deficiency (i.e., Vit-D <20 ng/mL) or severe Vit-D deficiency (i.e., Vit-D <12 ng/mL) and those without (31% vs 35% with P = 0.649, and 34% vs 30% with P = 0.593, respectively). Vit-D level and status (i.e., Vit-D deficiency and severe Vit-D deficiency) were not prospectively associated with the risk of the composite endpoint of ICU admission/in-hospital death (P > 0.05 for all Cox regression models). Conclusions: Regardless of the potential usefulness of Vit-D measurement to guide appropriate supplementation, Vit-D does not appear to provide helpful information for the stratification of in-hospital prognosis in patients with COVID-19. |
format | Online Article Text |
id | pubmed-8247197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82471972021-07-02 Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 Bianconi, Vanessa Mannarino, Massimo R. Figorilli, Filippo Cosentini, Elena Batori, Giuseppe Marini, Ettore Lombardini, Rita Gargaro, Marco Fallarino, Francesca Scarponi, Anna Maria Sahebkar, Amirhossein Pirro, Matteo Nutrition Applied Nutritional Investigation Objectives: Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 (COVID-19), its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The association between Vit-D and the composite endpoint of intensive care unit (ICU) admission/in-hospital death was explored using univariable and multivariable analyses. Also, serum Vit-D level in patients with COVID-19 was compared with that in age- and sex-balanced COVID-19-negative controls (i.e., 50 inpatients with sepsis). Results: Serum Vit-D level was comparable between patients with COVID-19 and COVID-19-negative inpatients with sepsis (P = 0.397). No significant differences were found in serum Vit-D level according to COVID-19 severity at the time of hospital admission (P = 0.299). Incidence rates of the composite endpoint of ICU admission/in-hospital death did not differ significantly between patients with either Vit-D deficiency (i.e., Vit-D <20 ng/mL) or severe Vit-D deficiency (i.e., Vit-D <12 ng/mL) and those without (31% vs 35% with P = 0.649, and 34% vs 30% with P = 0.593, respectively). Vit-D level and status (i.e., Vit-D deficiency and severe Vit-D deficiency) were not prospectively associated with the risk of the composite endpoint of ICU admission/in-hospital death (P > 0.05 for all Cox regression models). Conclusions: Regardless of the potential usefulness of Vit-D measurement to guide appropriate supplementation, Vit-D does not appear to provide helpful information for the stratification of in-hospital prognosis in patients with COVID-19. Elsevier Inc. 2021 2021-07-01 /pmc/articles/PMC8247197/ /pubmed/34388589 http://dx.doi.org/10.1016/j.nut.2021.111408 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Applied Nutritional Investigation Bianconi, Vanessa Mannarino, Massimo R. Figorilli, Filippo Cosentini, Elena Batori, Giuseppe Marini, Ettore Lombardini, Rita Gargaro, Marco Fallarino, Francesca Scarponi, Anna Maria Sahebkar, Amirhossein Pirro, Matteo Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 |
title | Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 |
title_full | Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 |
title_fullStr | Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 |
title_full_unstemmed | Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 |
title_short | Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 |
title_sort | prevalence of vitamin d deficiency and its prognostic impact on patients hospitalized with covid-19 |
topic | Applied Nutritional Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247197/ https://www.ncbi.nlm.nih.gov/pubmed/34388589 http://dx.doi.org/10.1016/j.nut.2021.111408 |
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