Cargando…

Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19

Objectives: Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 (COVID-19), its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The asso...

Descripción completa

Detalles Bibliográficos
Autores principales: Bianconi, Vanessa, Mannarino, Massimo R., Figorilli, Filippo, Cosentini, Elena, Batori, Giuseppe, Marini, Ettore, Lombardini, Rita, Gargaro, Marco, Fallarino, Francesca, Scarponi, Anna Maria, Sahebkar, Amirhossein, Pirro, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247197/
https://www.ncbi.nlm.nih.gov/pubmed/34388589
http://dx.doi.org/10.1016/j.nut.2021.111408
_version_ 1783716471087562752
author Bianconi, Vanessa
Mannarino, Massimo R.
Figorilli, Filippo
Cosentini, Elena
Batori, Giuseppe
Marini, Ettore
Lombardini, Rita
Gargaro, Marco
Fallarino, Francesca
Scarponi, Anna Maria
Sahebkar, Amirhossein
Pirro, Matteo
author_facet Bianconi, Vanessa
Mannarino, Massimo R.
Figorilli, Filippo
Cosentini, Elena
Batori, Giuseppe
Marini, Ettore
Lombardini, Rita
Gargaro, Marco
Fallarino, Francesca
Scarponi, Anna Maria
Sahebkar, Amirhossein
Pirro, Matteo
author_sort Bianconi, Vanessa
collection PubMed
description Objectives: Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 (COVID-19), its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The association between Vit-D and the composite endpoint of intensive care unit (ICU) admission/in-hospital death was explored using univariable and multivariable analyses. Also, serum Vit-D level in patients with COVID-19 was compared with that in age- and sex-balanced COVID-19-negative controls (i.e., 50 inpatients with sepsis). Results: Serum Vit-D level was comparable between patients with COVID-19 and COVID-19-negative inpatients with sepsis (P = 0.397). No significant differences were found in serum Vit-D level according to COVID-19 severity at the time of hospital admission (P = 0.299). Incidence rates of the composite endpoint of ICU admission/in-hospital death did not differ significantly between patients with either Vit-D deficiency (i.e., Vit-D <20 ng/mL) or severe Vit-D deficiency (i.e., Vit-D <12 ng/mL) and those without (31% vs 35% with P = 0.649, and 34% vs 30% with P = 0.593, respectively). Vit-D level and status (i.e., Vit-D deficiency and severe Vit-D deficiency) were not prospectively associated with the risk of the composite endpoint of ICU admission/in-hospital death (P > 0.05 for all Cox regression models). Conclusions: Regardless of the potential usefulness of Vit-D measurement to guide appropriate supplementation, Vit-D does not appear to provide helpful information for the stratification of in-hospital prognosis in patients with COVID-19.
format Online
Article
Text
id pubmed-8247197
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-82471972021-07-02 Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19 Bianconi, Vanessa Mannarino, Massimo R. Figorilli, Filippo Cosentini, Elena Batori, Giuseppe Marini, Ettore Lombardini, Rita Gargaro, Marco Fallarino, Francesca Scarponi, Anna Maria Sahebkar, Amirhossein Pirro, Matteo Nutrition Applied Nutritional Investigation Objectives: Although hypovitaminosis D appears to be highly prevalent in patients with coronavirus disease 2019 (COVID-19), its impact on their prognosis remains unclear. Methods: In this study, serum 25-hydroxyvitamin D (Vit-D) level was measured in 200 patients hospitalized with COVID-19. The association between Vit-D and the composite endpoint of intensive care unit (ICU) admission/in-hospital death was explored using univariable and multivariable analyses. Also, serum Vit-D level in patients with COVID-19 was compared with that in age- and sex-balanced COVID-19-negative controls (i.e., 50 inpatients with sepsis). Results: Serum Vit-D level was comparable between patients with COVID-19 and COVID-19-negative inpatients with sepsis (P = 0.397). No significant differences were found in serum Vit-D level according to COVID-19 severity at the time of hospital admission (P = 0.299). Incidence rates of the composite endpoint of ICU admission/in-hospital death did not differ significantly between patients with either Vit-D deficiency (i.e., Vit-D <20 ng/mL) or severe Vit-D deficiency (i.e., Vit-D <12 ng/mL) and those without (31% vs 35% with P = 0.649, and 34% vs 30% with P = 0.593, respectively). Vit-D level and status (i.e., Vit-D deficiency and severe Vit-D deficiency) were not prospectively associated with the risk of the composite endpoint of ICU admission/in-hospital death (P > 0.05 for all Cox regression models). Conclusions: Regardless of the potential usefulness of Vit-D measurement to guide appropriate supplementation, Vit-D does not appear to provide helpful information for the stratification of in-hospital prognosis in patients with COVID-19. Elsevier Inc. 2021 2021-07-01 /pmc/articles/PMC8247197/ /pubmed/34388589 http://dx.doi.org/10.1016/j.nut.2021.111408 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Applied Nutritional Investigation
Bianconi, Vanessa
Mannarino, Massimo R.
Figorilli, Filippo
Cosentini, Elena
Batori, Giuseppe
Marini, Ettore
Lombardini, Rita
Gargaro, Marco
Fallarino, Francesca
Scarponi, Anna Maria
Sahebkar, Amirhossein
Pirro, Matteo
Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
title Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
title_full Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
title_fullStr Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
title_full_unstemmed Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
title_short Prevalence of vitamin D deficiency and its prognostic impact on patients hospitalized with COVID-19
title_sort prevalence of vitamin d deficiency and its prognostic impact on patients hospitalized with covid-19
topic Applied Nutritional Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247197/
https://www.ncbi.nlm.nih.gov/pubmed/34388589
http://dx.doi.org/10.1016/j.nut.2021.111408
work_keys_str_mv AT bianconivanessa prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT mannarinomassimor prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT figorillifilippo prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT cosentinielena prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT batorigiuseppe prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT mariniettore prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT lombardinirita prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT gargaromarco prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT fallarinofrancesca prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT scarponiannamaria prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT sahebkaramirhossein prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19
AT pirromatteo prevalenceofvitaminddeficiencyanditsprognosticimpactonpatientshospitalizedwithcovid19