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Weakly correlated activity of pallidal neurons in behaving monkeys

The basal ganglia play a crucial role in the control of voluntary movements. Neurons in both the external and internal segments of the globus pallidus, the connecting and output nuclei of the basal ganglia, respectively, change their firing rates in relation to movements. Firing rate changes of move...

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Autores principales: Wongmassang, Woranan, Hasegawa, Taku, Chiken, Satomi, Nambu, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247335/
https://www.ncbi.nlm.nih.gov/pubmed/32649021
http://dx.doi.org/10.1111/ejn.14903
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author Wongmassang, Woranan
Hasegawa, Taku
Chiken, Satomi
Nambu, Atsushi
author_facet Wongmassang, Woranan
Hasegawa, Taku
Chiken, Satomi
Nambu, Atsushi
author_sort Wongmassang, Woranan
collection PubMed
description The basal ganglia play a crucial role in the control of voluntary movements. Neurons in both the external and internal segments of the globus pallidus, the connecting and output nuclei of the basal ganglia, respectively, change their firing rates in relation to movements. Firing rate changes of movement‐related neurons seem to convey signals for motor control. On the other hand, coincident spikes among neurons, that is, correlated activity, may also contribute to motor control. To address this issue, we first identified multiple pallidal neurons receiving inputs from the forelimb regions of the primary motor cortex and supplementary motor area, recorded neuronal activity of these neurons simultaneously, and analyzed their spike correlations while monkeys performed a hand‐reaching task. Most (79%) pallidal neurons exhibited task‐related firing rate changes, whereas only a small fraction (20%) showed significant but small and short correlated activity during the task performance. These results suggest that motor control signals are conveyed primarily by firing rate changes in the external and internal segments of the globus pallidus and that the contribution of correlated activity may play only a minor role in the healthy state.
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spelling pubmed-82473352021-07-02 Weakly correlated activity of pallidal neurons in behaving monkeys Wongmassang, Woranan Hasegawa, Taku Chiken, Satomi Nambu, Atsushi Eur J Neurosci Special Issue Articles The basal ganglia play a crucial role in the control of voluntary movements. Neurons in both the external and internal segments of the globus pallidus, the connecting and output nuclei of the basal ganglia, respectively, change their firing rates in relation to movements. Firing rate changes of movement‐related neurons seem to convey signals for motor control. On the other hand, coincident spikes among neurons, that is, correlated activity, may also contribute to motor control. To address this issue, we first identified multiple pallidal neurons receiving inputs from the forelimb regions of the primary motor cortex and supplementary motor area, recorded neuronal activity of these neurons simultaneously, and analyzed their spike correlations while monkeys performed a hand‐reaching task. Most (79%) pallidal neurons exhibited task‐related firing rate changes, whereas only a small fraction (20%) showed significant but small and short correlated activity during the task performance. These results suggest that motor control signals are conveyed primarily by firing rate changes in the external and internal segments of the globus pallidus and that the contribution of correlated activity may play only a minor role in the healthy state. John Wiley and Sons Inc. 2020-07-27 2021-04 /pmc/articles/PMC8247335/ /pubmed/32649021 http://dx.doi.org/10.1111/ejn.14903 Text en © 2020 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Special Issue Articles
Wongmassang, Woranan
Hasegawa, Taku
Chiken, Satomi
Nambu, Atsushi
Weakly correlated activity of pallidal neurons in behaving monkeys
title Weakly correlated activity of pallidal neurons in behaving monkeys
title_full Weakly correlated activity of pallidal neurons in behaving monkeys
title_fullStr Weakly correlated activity of pallidal neurons in behaving monkeys
title_full_unstemmed Weakly correlated activity of pallidal neurons in behaving monkeys
title_short Weakly correlated activity of pallidal neurons in behaving monkeys
title_sort weakly correlated activity of pallidal neurons in behaving monkeys
topic Special Issue Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247335/
https://www.ncbi.nlm.nih.gov/pubmed/32649021
http://dx.doi.org/10.1111/ejn.14903
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