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Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women
Background: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women. Method: We went through a registry of spontaneous ICH cases and selecte...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247568/ https://www.ncbi.nlm.nih.gov/pubmed/34220692 http://dx.doi.org/10.3389/fneur.2021.690194 |
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author | Feng, Hao Wang, Xin Wang, Wenjuan Zhao, Xingquan |
author_facet | Feng, Hao Wang, Xin Wang, Wenjuan Zhao, Xingquan |
author_sort | Feng, Hao |
collection | PubMed |
description | Background: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women. Method: We went through a registry of spontaneous ICH cases and selected female patients to study according to our criteria. We collected demographic, clinical, and laboratory information and evaluated serum triglyceride (TG) levels, total cholesterol (TC) levels, low-density cholesterol (LDLC) levels, high-density cholesterol (HDLC) levels, non-high-density cholesterol (non-HDLC) levels, and 3-month modified Rankin Scale (mRS). Multivariate logistic regression was performed, and receiver operating characteristic (ROC) curves were plotted to explore the relationship between serum lipid levels and 3-month ICH clinical outcomes. Results: Two hundred six female patients were included in this study, and 96 (46.6%) of them had poor functional outcomes. In the univariate analysis, low TG (p = 0.006), TC (p = 0.025), LDLC (p = 0.001), non-HDLC (p < 0.001) levels, and high HDL (p = 0.036) levels were associated with poor 3-month clinical outcomes in women. In the multivariate logistic regression, low levels of TG (OR = 0.711, 95% CI = 0.542–0.933, p = 0.014), TC (OR = 0.523, 95% CI = 0.304–0.903, p = 0.020), LDLC (OR = 0.538, 95% CI = 0.307–0.942, p = 0.030), non-HDLC (OR = 0.327, 95% CI = 0.177–0.603, p < 0.001), and a high level of HDLC (OR = 2.075, 95% CI = 1.064–4.047, p = 0.032) with area under the curve (AUC) of 0.610, 0.590, 0.630, 0.645, and 0.415, respectively, remained as independent indicators of poor prognosis at 3 months after adjusting for confounding factors. Conclusion: Low levels of TG, TC, LDLC, non-HDLC, and high levels of HDLC were independently associated with poor prognosis of spontaneous ICH in women. |
format | Online Article Text |
id | pubmed-8247568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82475682021-07-02 Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women Feng, Hao Wang, Xin Wang, Wenjuan Zhao, Xingquan Front Neurol Neurology Background: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women. Method: We went through a registry of spontaneous ICH cases and selected female patients to study according to our criteria. We collected demographic, clinical, and laboratory information and evaluated serum triglyceride (TG) levels, total cholesterol (TC) levels, low-density cholesterol (LDLC) levels, high-density cholesterol (HDLC) levels, non-high-density cholesterol (non-HDLC) levels, and 3-month modified Rankin Scale (mRS). Multivariate logistic regression was performed, and receiver operating characteristic (ROC) curves were plotted to explore the relationship between serum lipid levels and 3-month ICH clinical outcomes. Results: Two hundred six female patients were included in this study, and 96 (46.6%) of them had poor functional outcomes. In the univariate analysis, low TG (p = 0.006), TC (p = 0.025), LDLC (p = 0.001), non-HDLC (p < 0.001) levels, and high HDL (p = 0.036) levels were associated with poor 3-month clinical outcomes in women. In the multivariate logistic regression, low levels of TG (OR = 0.711, 95% CI = 0.542–0.933, p = 0.014), TC (OR = 0.523, 95% CI = 0.304–0.903, p = 0.020), LDLC (OR = 0.538, 95% CI = 0.307–0.942, p = 0.030), non-HDLC (OR = 0.327, 95% CI = 0.177–0.603, p < 0.001), and a high level of HDLC (OR = 2.075, 95% CI = 1.064–4.047, p = 0.032) with area under the curve (AUC) of 0.610, 0.590, 0.630, 0.645, and 0.415, respectively, remained as independent indicators of poor prognosis at 3 months after adjusting for confounding factors. Conclusion: Low levels of TG, TC, LDLC, non-HDLC, and high levels of HDLC were independently associated with poor prognosis of spontaneous ICH in women. Frontiers Media S.A. 2021-06-17 /pmc/articles/PMC8247568/ /pubmed/34220692 http://dx.doi.org/10.3389/fneur.2021.690194 Text en Copyright © 2021 Feng, Wang, Wang and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Feng, Hao Wang, Xin Wang, Wenjuan Zhao, Xingquan Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
title | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
title_full | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
title_fullStr | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
title_full_unstemmed | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
title_short | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
title_sort | lipid levels and 3-month prognosis after spontaneous intracerebral hemorrhage in women |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247568/ https://www.ncbi.nlm.nih.gov/pubmed/34220692 http://dx.doi.org/10.3389/fneur.2021.690194 |
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