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Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium

Small GTPase Rap1 plays a prominent role in endothelial cell (EC) homeostasis by promoting NO release. Endothelial deletion of the two highly homologous Rap1 isoforms, Rap1A and Rap1B, leads to endothelial dysfunction ex vivo and hypertension in vivo. Mechanistically, we showed that Rap1B promotes N...

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Detalles Bibliográficos
Autores principales:	Kosuru, Ramoji, Singh, Bandana, Lakshmikanthan, Sribalaji, Nishijima, Yoshinori, Vasquez-Vivar, Jeannette, Zhang, David X., Chrzanowska, Magdalena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247587/ https://www.ncbi.nlm.nih.gov/pubmed/34222255 http://dx.doi.org/10.3389/fcell.2021.687598

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