Targeting the m(6)A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication

N(6)-methyladenosine (m(6)A) is an abundant internal RNA modification, influencing transcript fate and function in uninfected and virus-infected cells. Installation of m(6)A by the nuclear RNA methyltransferase METTL3 occurs cotranscriptionally; however, the genomes of some cytoplasmic RNA viruses a...

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Detalles Bibliográficos
Autores principales: Burgess, Hannah M., Depledge, Daniel P., Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C., Vink, Elizabeth I., Abebe, Jonathan S., Blackaby, Wesley P., Hendrick, Alan, Albertella, Mark R., Kouzarides, Tony, Stapleford, Kenneth A., Wilson, Angus C., Mohr, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247602/
https://www.ncbi.nlm.nih.gov/pubmed/34168039
http://dx.doi.org/10.1101/gad.348320.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247602/
https://www.ncbi.nlm.nih.gov/pubmed/34168039
http://dx.doi.org/10.1101/gad.348320.121

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