Cargando…

The biological underpinnings of therapeutic resistance in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal prognosis reflects the remarkable capacity of PDAC to effectively adapt to and resist therapeutic intervention. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beatty, Gregory L., Werba, Gregor, Lyssiotis, Costas A., Simeone, Diane M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247606/ https://www.ncbi.nlm.nih.gov/pubmed/34117095 http://dx.doi.org/10.1101/gad.348523.121

Ejemplares similares

Metabolic Regulation of Redox Balance in Cancer
por: Purohit, Vinee, et al.
Publicado: (2019)

Social and Biological Transgenerational Underpinnings of Adolescent Pregnancy
por: Rowlands, Amanda, et al.
Publicado: (2021)

Cyst fluid metabolites distinguish malignant from benign pancreatic cysts
por: Shi, Jiaqi, et al.
Publicado: (2021)

Biological Factors Underpinning Suicidal Behaviour: An Update
por: Abou Chahla, Maya N., et al.
Publicado: (2023)

Biological mechanisms underpinning the development of long COVID
por: Perumal, Rubeshan, et al.
Publicado: (2023)

Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies
por: Wan, Shanshan, et al.
Publicado: (2023)

Corrigendum: Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies
por: Wan, Shanshan, et al.
Publicado: (2023)

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
por: Lyssiotis, Costas A., et al.
Publicado: (2013)

Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer
por: Lee, Jesse, et al.
Publicado: (2021)

Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular
por: Chandolu, Vijay, et al.
Publicado: (2012)

Pancreatic cancers depend on a non-canonical glutamine metabolism pathway
por: Lyssiotis, Costas, et al.
Publicado: (2014)

Pushing the Envelope: Developments in Neural Entrainment to Speech and the Biological Underpinnings of Prosody Perception
por: Myers, Brett R., et al.
Publicado: (2019)

The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms
por: Chand, Saswati, et al.
Publicado: (2016)

Social ‘wanting’ dysfunction in autism: neurobiological underpinnings and treatment implications
por: Kohls, Gregor, et al.
Publicado: (2012)

Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance
por: Leonardo-Sousa, Carlota, et al.
Publicado: (2022)

Metabolic Reprogramming and Vulnerabilities in Cancer
por: Lyssiotis, Costas A., et al.
Publicado: (2019)

MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential
por: Rawat, Manmeet, et al.
Publicado: (2019)

Negative resistance and resilience: biotic mechanisms underpin delayed biological recovery in stream restoration
por: Barrett, Isabelle C., et al.
Publicado: (2021)

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer
por: Zhang, Yaqing, et al.
Publicado: (2017)

Metabolic regulation of ferroptosis in the tumor microenvironment
por: Mbah, Nneka E., et al.
Publicado: (2022)

A Review of Key Biological and Molecular Events Underpinning Transformation of Melanocytes to Primary and Metastatic Melanoma
por: Jackett, Louise A., et al.
Publicado: (2019)

The underpinnings of cerebellar ataxias
por: Manto, Mario
Publicado: (2022)

Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer
por: Son, Seung Wan, et al.
Publicado: (2021)

Vascular underpinning of COVID-19
por: Wazny, Vanessa, et al.
Publicado: (2020)

Editorial: Pathways and Processes Underpinning Axonal Biology and Pathobiology
por: Sahoo, Pabitra K., et al.
Publicado: (2022)

ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer
por: Purohit, Vinee, et al.
Publicado: (2021)

Focusing on the Neuro-Psycho-Biological and Evolutionary Underpinnings of the Imposter Syndrome
por: Chrousos, George P., et al.
Publicado: (2020)

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics
por: de Vos, Cato M. H., et al.
Publicado: (2021)

The Coevolution of Plants and Microbes Underpins Sustainable Agriculture
por: Lyu, Dongmei, et al.
Publicado: (2021)

Historical Underpinnings of Bipolar Disorder Diagnostic Criteria
por: Mason, Brittany L., et al.
Publicado: (2016)

Spotlight on GOT2 in Cancer Metabolism
por: Kerk, Samuel A, et al.
Publicado: (2023)

Oncolytic HSV: Underpinnings of Tumor Susceptibility
por: Kangas, Chase, et al.
Publicado: (2021)

Unravelling the Role of Kinases That Underpin Androgen Signalling in Prostate Cancer
por: Miller, Katie Joanna, et al.
Publicado: (2022)

Postpartum depression: psychoneuroimmunological underpinnings and treatment
por: Anderson, George, et al.
Publicado: (2013)

The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature
por: Dougherty, Mark C., et al.
Publicado: (2021)

A Research Agenda to Underpin Malaria Eradication
por: Alonso, Pedro L., et al.
Publicado: (2011)

Macrophage-based immunotherapy for the treatment of pancreatic ductal adenocarcinoma
por: Beatty, Gregory L
Publicado: (2013)

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics
por: Lee, Ho-Joon, et al.
Publicado: (2019)

POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling
por: Oh, Grace, et al.
Publicado: (2023)

The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia
por: Vellucci, Licia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cas23u3t2ohahv4jm51c9etvu4