α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia

Synucleinopathies such as Parkinson's disease (PD) are hallmarked by α‐synuclein (α‐syn) pathology and neuroinflammation. This neuroinflammation involves activated microglia with increased secretion of interleukin‐1β (IL‐1β). The main driver of IL‐1β secretion from microglia is the NLRP3 inflam...

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Detalles Bibliográficos
Autores principales: Pike, Adrianne F., Varanita, Tatiana, Herrebout, Maaike A. C., Plug, Bonnie C., Kole, Jeroen, Musters, René J. P., Teunissen, Charlotte E., Hoozemans, Jeroen J. M., Bubacco, Luigi, Veerhuis, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247862/
https://www.ncbi.nlm.nih.gov/pubmed/33506583
http://dx.doi.org/10.1002/glia.23970

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