A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study

BACKGROUND: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. METHODS: We collected data from 1581 patients. A cause‐specific Cox model for the development of...

Descripción completa

Detalles Bibliográficos
Autores principales: Bugter, Oisín, van Iwaarden, Dirk L. P., van Leeuwen, Nikki, Nieboer, Daan, Dronkers, Emilie A. C., Hardillo, José A. U., Baatenburg de Jong, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247881/
https://www.ncbi.nlm.nih.gov/pubmed/33655596
http://dx.doi.org/10.1002/hed.26666
Descripción
Sumario:BACKGROUND: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. METHODS: We collected data from 1581 patients. A cause‐specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. RESULTS: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C‐index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). CONCLUSIONS: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations.

Ejemplares similares