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A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study
BACKGROUND: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. METHODS: We collected data from 1581 patients. A cause‐specific Cox model for the development of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247881/ https://www.ncbi.nlm.nih.gov/pubmed/33655596 http://dx.doi.org/10.1002/hed.26666 |
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author | Bugter, Oisín van Iwaarden, Dirk L. P. van Leeuwen, Nikki Nieboer, Daan Dronkers, Emilie A. C. Hardillo, José A. U. Baatenburg de Jong, Robert J. |
author_facet | Bugter, Oisín van Iwaarden, Dirk L. P. van Leeuwen, Nikki Nieboer, Daan Dronkers, Emilie A. C. Hardillo, José A. U. Baatenburg de Jong, Robert J. |
author_sort | Bugter, Oisín |
collection | PubMed |
description | BACKGROUND: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. METHODS: We collected data from 1581 patients. A cause‐specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. RESULTS: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C‐index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). CONCLUSIONS: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations. |
format | Online Article Text |
id | pubmed-8247881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82478812021-07-02 A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study Bugter, Oisín van Iwaarden, Dirk L. P. van Leeuwen, Nikki Nieboer, Daan Dronkers, Emilie A. C. Hardillo, José A. U. Baatenburg de Jong, Robert J. Head Neck Original Articles BACKGROUND: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. METHODS: We collected data from 1581 patients. A cause‐specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. RESULTS: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C‐index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). CONCLUSIONS: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations. John Wiley & Sons, Inc. 2021-03-03 2021-06 /pmc/articles/PMC8247881/ /pubmed/33655596 http://dx.doi.org/10.1002/hed.26666 Text en © 2021 The Authors. Head & Neck published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Bugter, Oisín van Iwaarden, Dirk L. P. van Leeuwen, Nikki Nieboer, Daan Dronkers, Emilie A. C. Hardillo, José A. U. Baatenburg de Jong, Robert J. A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study |
title | A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study |
title_full | A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study |
title_fullStr | A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study |
title_full_unstemmed | A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study |
title_short | A cause‐specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study |
title_sort | cause‐specific cox model for second primary tumors in patients with head and neck cancer: a roncdoc study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247881/ https://www.ncbi.nlm.nih.gov/pubmed/33655596 http://dx.doi.org/10.1002/hed.26666 |
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