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Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study
AIM: To determine whether a dose‐dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon‐like peptide‐1 [aGLP‐1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol. MATERIALS AND METHODS: Twelve healthy, lean volunteer...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247993/ https://www.ncbi.nlm.nih.gov/pubmed/33565706 http://dx.doi.org/10.1111/dom.14342 |
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author | Wölnerhanssen, Bettina K. Drewe, Jürgen Verbeure, Wout le Roux, Carel W. Dellatorre‐Teixeira, Ludmilla Rehfeld, Jens F. Holst, Jens J. Hartmann, Bolette Tack, Jan Peterli, Ralph Beglinger, Christoph Meyer‐Gerspach, Anne C. |
author_facet | Wölnerhanssen, Bettina K. Drewe, Jürgen Verbeure, Wout le Roux, Carel W. Dellatorre‐Teixeira, Ludmilla Rehfeld, Jens F. Holst, Jens J. Hartmann, Bolette Tack, Jan Peterli, Ralph Beglinger, Christoph Meyer‐Gerspach, Anne C. |
author_sort | Wölnerhanssen, Bettina K. |
collection | PubMed |
description | AIM: To determine whether a dose‐dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon‐like peptide‐1 [aGLP‐1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol. MATERIALS AND METHODS: Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with (13)C‐sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo‐controlled, double‐blind, cross‐over trial. Blood samples and breath samples ((13)C‐sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated. RESULTS: We found (a) a dose‐dependent stimulation of CCK, aGLP‐1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose‐dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting. CONCLUSIONS: Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol‐containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated. |
format | Online Article Text |
id | pubmed-8247993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-82479932021-07-02 Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study Wölnerhanssen, Bettina K. Drewe, Jürgen Verbeure, Wout le Roux, Carel W. Dellatorre‐Teixeira, Ludmilla Rehfeld, Jens F. Holst, Jens J. Hartmann, Bolette Tack, Jan Peterli, Ralph Beglinger, Christoph Meyer‐Gerspach, Anne C. Diabetes Obes Metab Original Articles AIM: To determine whether a dose‐dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon‐like peptide‐1 [aGLP‐1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol. MATERIALS AND METHODS: Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with (13)C‐sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo‐controlled, double‐blind, cross‐over trial. Blood samples and breath samples ((13)C‐sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated. RESULTS: We found (a) a dose‐dependent stimulation of CCK, aGLP‐1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose‐dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting. CONCLUSIONS: Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol‐containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated. Blackwell Publishing Ltd 2021-02-26 2021-06 /pmc/articles/PMC8247993/ /pubmed/33565706 http://dx.doi.org/10.1111/dom.14342 Text en © 2021 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Wölnerhanssen, Bettina K. Drewe, Jürgen Verbeure, Wout le Roux, Carel W. Dellatorre‐Teixeira, Ludmilla Rehfeld, Jens F. Holst, Jens J. Hartmann, Bolette Tack, Jan Peterli, Ralph Beglinger, Christoph Meyer‐Gerspach, Anne C. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study |
title | Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study |
title_full | Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study |
title_fullStr | Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study |
title_full_unstemmed | Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study |
title_short | Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study |
title_sort | gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: a pilot dose‐ranging study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247993/ https://www.ncbi.nlm.nih.gov/pubmed/33565706 http://dx.doi.org/10.1111/dom.14342 |
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