Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a...

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Detalles Bibliográficos
Autores principales: Talibov, Vladimir O., Fabini, Edoardo, FitzGerald, Edward A., Tedesco, Daniele, Cederfeldt, Daniela, Talu, Martin J., Rachman, Moira M., Mihalic, Filip, Manoni, Elisabetta, Naldi, Marina, Sanese, Paola, Forte, Giovanna, Lepore Signorile, Martina, Barril, Xavier, Simone, Cristiano, Bartolini, Manuela, Dobritzsch, Doreen, Del Rio, Alberto, Danielson, U. Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248052/
https://www.ncbi.nlm.nih.gov/pubmed/33400854
http://dx.doi.org/10.1002/cbic.202000736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248052/
https://www.ncbi.nlm.nih.gov/pubmed/33400854
http://dx.doi.org/10.1002/cbic.202000736

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