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Differential Inhibition of LRRK2 in Parkinson's Disease Patient Blood by a G2019S Selective LRRK2 Inhibitor

BACKGROUND: A common genetic mutation that causes Parkinson's disease (PD) is the G2019S LRRK2 mutation. A precision medicine approach that selectively blocks only excess kinase activity of the mutant allele could yield a safe and effective treatment for G2019S LRRK2 PD. OBJECTIVE: To determine...

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Detalles Bibliográficos
Autores principales:	Bright, Jessica M., Carlisle, Holly J., Toda, Alyssa M. A., Murphy, Molly, Molitor, Tyler P., Wren, Paul, Andruska, Kristin M., Liu, Enchi, Barlow, Carrolee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Regular Issue Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248170/ https://www.ncbi.nlm.nih.gov/pubmed/33836114 http://dx.doi.org/10.1002/mds.28490

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