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Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer

Prostate cancer (PCA) is the second leading cause of cancer-related mortality in men. The glycolytic enzymes hexokinase II (HKII) and the major regulator hypoxia-inducible factor-1α (HIF-1α) are PCA-specific biomarkers. Some studies have shown that HKII and HIF-1α are highly expressive in PCA and ar...

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Autores principales: Sun, Xueqi, Huang, Qirui, Peng, Fang, Wang, Jian, Zhao, Weidong, Guo, Guangxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248182/
https://www.ncbi.nlm.nih.gov/pubmed/34220956
http://dx.doi.org/10.3389/fgene.2021.680928
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author Sun, Xueqi
Huang, Qirui
Peng, Fang
Wang, Jian
Zhao, Weidong
Guo, Guangxiu
author_facet Sun, Xueqi
Huang, Qirui
Peng, Fang
Wang, Jian
Zhao, Weidong
Guo, Guangxiu
author_sort Sun, Xueqi
collection PubMed
description Prostate cancer (PCA) is the second leading cause of cancer-related mortality in men. The glycolytic enzymes hexokinase II (HKII) and the major regulator hypoxia-inducible factor-1α (HIF-1α) are PCA-specific biomarkers. Some studies have shown that HKII and HIF-1α are highly expressive in PCA and are associated with the growth and metastasis of treatment. Whether HKII and HIF-1α regulate the different differentiation of PCA remains largely unknown. Therefore, the study aims to explore the value of HKII and HIF-1α in different grade groups of PCA. Our data indicated that compared with normal prostate tissues, the level of mRNA and protein of HKII and HIF-1α in PCA increased significantly, besides the results showed the high expression of HKII and HIF-1α had a tendency to promote the progression and differentiation of PCA. The study also found that HKII expression was positively correlated with the expression of HIF-1α. HKII and HIF-1α were related to the degree of differentiation PCA, especially in high-grade PCA. Furthermore, the high expression of HKII was significantly associated with Gleason score and histological differentiation in clinicopathological characteristics of patients with PCA. These results were further used to confirm that the expression of HKII and HIF-1α was associated with the progression and differentiation of PCA. These experiments indicated that HKII and HIF-1α might be novel biomarkers of PCA with potential clinical application value, provide a new potential target for PCA treatment, and are expected to be used for individualized treatment in patients with PCA.
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spelling pubmed-82481822021-07-02 Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer Sun, Xueqi Huang, Qirui Peng, Fang Wang, Jian Zhao, Weidong Guo, Guangxiu Front Genet Genetics Prostate cancer (PCA) is the second leading cause of cancer-related mortality in men. The glycolytic enzymes hexokinase II (HKII) and the major regulator hypoxia-inducible factor-1α (HIF-1α) are PCA-specific biomarkers. Some studies have shown that HKII and HIF-1α are highly expressive in PCA and are associated with the growth and metastasis of treatment. Whether HKII and HIF-1α regulate the different differentiation of PCA remains largely unknown. Therefore, the study aims to explore the value of HKII and HIF-1α in different grade groups of PCA. Our data indicated that compared with normal prostate tissues, the level of mRNA and protein of HKII and HIF-1α in PCA increased significantly, besides the results showed the high expression of HKII and HIF-1α had a tendency to promote the progression and differentiation of PCA. The study also found that HKII expression was positively correlated with the expression of HIF-1α. HKII and HIF-1α were related to the degree of differentiation PCA, especially in high-grade PCA. Furthermore, the high expression of HKII was significantly associated with Gleason score and histological differentiation in clinicopathological characteristics of patients with PCA. These results were further used to confirm that the expression of HKII and HIF-1α was associated with the progression and differentiation of PCA. These experiments indicated that HKII and HIF-1α might be novel biomarkers of PCA with potential clinical application value, provide a new potential target for PCA treatment, and are expected to be used for individualized treatment in patients with PCA. Frontiers Media S.A. 2021-06-17 /pmc/articles/PMC8248182/ /pubmed/34220956 http://dx.doi.org/10.3389/fgene.2021.680928 Text en Copyright © 2021 Sun, Huang, Peng, Wang, Zhao and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Sun, Xueqi
Huang, Qirui
Peng, Fang
Wang, Jian
Zhao, Weidong
Guo, Guangxiu
Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer
title Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer
title_full Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer
title_fullStr Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer
title_full_unstemmed Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer
title_short Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer
title_sort expression and clinical significance of hkii and hif-1α in grade groups of prostate cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248182/
https://www.ncbi.nlm.nih.gov/pubmed/34220956
http://dx.doi.org/10.3389/fgene.2021.680928
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