Intermolecular Hydroaminoalkylation of Alkynes

Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as...

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Detalles Bibliográficos
Autores principales: Kaper, Tobias, Fischer, Malte, Thye, Hermann, Geik, Dennis, Schmidtmann, Marc, Beckhaus, Ruediger, Doye, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248392/
https://www.ncbi.nlm.nih.gov/pubmed/33481309
http://dx.doi.org/10.1002/chem.202100238
Descripción
Sumario:Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as well as a terminal alkyne take place with N‐benzylanilines, N‐alkylanilines, and N‐alkylbenzylamines.

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