Intermolecular Hydroaminoalkylation of Alkynes

Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaper, Tobias, Fischer, Malte, Thye, Hermann, Geik, Dennis, Schmidtmann, Marc, Beckhaus, Ruediger, Doye, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248392/
https://www.ncbi.nlm.nih.gov/pubmed/33481309
http://dx.doi.org/10.1002/chem.202100238
_version_ 1783716714053107712
author Kaper, Tobias
Fischer, Malte
Thye, Hermann
Geik, Dennis
Schmidtmann, Marc
Beckhaus, Ruediger
Doye, Sven
author_facet Kaper, Tobias
Fischer, Malte
Thye, Hermann
Geik, Dennis
Schmidtmann, Marc
Beckhaus, Ruediger
Doye, Sven
author_sort Kaper, Tobias
collection PubMed
description Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as well as a terminal alkyne take place with N‐benzylanilines, N‐alkylanilines, and N‐alkylbenzylamines.
format Online
Article
Text
id pubmed-8248392
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-82483922021-07-06 Intermolecular Hydroaminoalkylation of Alkynes Kaper, Tobias Fischer, Malte Thye, Hermann Geik, Dennis Schmidtmann, Marc Beckhaus, Ruediger Doye, Sven Chemistry Communications Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as well as a terminal alkyne take place with N‐benzylanilines, N‐alkylanilines, and N‐alkylbenzylamines. John Wiley and Sons Inc. 2021-02-08 2021-04-21 /pmc/articles/PMC8248392/ /pubmed/33481309 http://dx.doi.org/10.1002/chem.202100238 Text en © 2021 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Kaper, Tobias
Fischer, Malte
Thye, Hermann
Geik, Dennis
Schmidtmann, Marc
Beckhaus, Ruediger
Doye, Sven
Intermolecular Hydroaminoalkylation of Alkynes
title Intermolecular Hydroaminoalkylation of Alkynes
title_full Intermolecular Hydroaminoalkylation of Alkynes
title_fullStr Intermolecular Hydroaminoalkylation of Alkynes
title_full_unstemmed Intermolecular Hydroaminoalkylation of Alkynes
title_short Intermolecular Hydroaminoalkylation of Alkynes
title_sort intermolecular hydroaminoalkylation of alkynes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248392/
https://www.ncbi.nlm.nih.gov/pubmed/33481309
http://dx.doi.org/10.1002/chem.202100238
work_keys_str_mv AT kapertobias intermolecularhydroaminoalkylationofalkynes
AT fischermalte intermolecularhydroaminoalkylationofalkynes
AT thyehermann intermolecularhydroaminoalkylationofalkynes
AT geikdennis intermolecularhydroaminoalkylationofalkynes
AT schmidtmannmarc intermolecularhydroaminoalkylationofalkynes
AT beckhausruediger intermolecularhydroaminoalkylationofalkynes
AT doyesven intermolecularhydroaminoalkylationofalkynes

Ejemplares similares