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Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans

Lowering the activity of the Insulin/IGF-1 Signaling (IIS) cascade results in elevated stress resistance, enhanced protein homeostasis (proteostasis) and extended lifespan of worms, flies and mice. In the nematode Caenorhabditis elegans (C. elegans), the longevity phenotype that stems from IIS reduc...

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Detalles Bibliográficos
Autores principales:	Grushko, Danielle, Boocholez, Hana, Levine, Amir, Cohen, Ehud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248617/ https://www.ncbi.nlm.nih.gov/pubmed/34197476 http://dx.doi.org/10.1371/journal.pone.0243522

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