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Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection
BACKGROUND/AIMS: Hepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection. METHODS: Anti-HCV...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248640/ https://www.ncbi.nlm.nih.gov/pubmed/34197557 http://dx.doi.org/10.1371/journal.pone.0254028 |
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author | Liu, Hung-Yin Lin, Yi-Hung Lin, Pei-Ju Tsai, Pei-Chien Liu, Shu-Fen Huang, Ying-Chou Tsai, Jia-Jiun Huang, Ching-I Yeh, Ming-Lun Liang, Po-Cheng Lin, Zu-Yau Dai, Chia-Yen Huang, Jee-Fu Chuang, Wan-Long Huang, Chung-Feng Yu, Ming-Lung |
author_facet | Liu, Hung-Yin Lin, Yi-Hung Lin, Pei-Ju Tsai, Pei-Chien Liu, Shu-Fen Huang, Ying-Chou Tsai, Jia-Jiun Huang, Ching-I Yeh, Ming-Lun Liang, Po-Cheng Lin, Zu-Yau Dai, Chia-Yen Huang, Jee-Fu Chuang, Wan-Long Huang, Chung-Feng Yu, Ming-Lung |
author_sort | Liu, Hung-Yin |
collection | PubMed |
description | BACKGROUND/AIMS: Hepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection. METHODS: Anti-HCV seropositive patients who were treatment-naïve consecutively enrolled. Anti-HCV antibodies were detected using a commercially chemiluminescent microparticle immunoassay. HCV RNA was detected by real-time PCR method. RESULTS: A total of 1321 including1196 mono-infected and 125 HBV dually infected patients were analyzed. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001). Of the entire cohort, the anti-HCV cut-off value of 10 provided the best accuracy, 96.8%, with the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 98.9%, 99.7% and 87.3% respectively. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001) and 9.36 (AUROC 1.00, P<0.0001) in patients with HCV mono-infection and HBV dual-infection respectively. Among the HBV dually infected patients, the accuracy of anti-HCV titer in predicting HCV viremia reached up to 100% with the cut-off value of 9. All the patients were HCV-viremic if their anti-HCV titer was greater than 9 (PPV 100%). On the other hand, all the patients were HCV non-viremic if their anti-HCV titer was less than 9 (NPV 100%). CONCLUSIONS: Anti-HCV titer strongly predicted HCV viremia. This excellent performance could be generalized to either HCV mono-infected or HBV dually infected patients. |
format | Online Article Text |
id | pubmed-8248640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82486402021-07-09 Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection Liu, Hung-Yin Lin, Yi-Hung Lin, Pei-Ju Tsai, Pei-Chien Liu, Shu-Fen Huang, Ying-Chou Tsai, Jia-Jiun Huang, Ching-I Yeh, Ming-Lun Liang, Po-Cheng Lin, Zu-Yau Dai, Chia-Yen Huang, Jee-Fu Chuang, Wan-Long Huang, Chung-Feng Yu, Ming-Lung PLoS One Research Article BACKGROUND/AIMS: Hepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection. METHODS: Anti-HCV seropositive patients who were treatment-naïve consecutively enrolled. Anti-HCV antibodies were detected using a commercially chemiluminescent microparticle immunoassay. HCV RNA was detected by real-time PCR method. RESULTS: A total of 1321 including1196 mono-infected and 125 HBV dually infected patients were analyzed. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001). Of the entire cohort, the anti-HCV cut-off value of 10 provided the best accuracy, 96.8%, with the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 98.9%, 99.7% and 87.3% respectively. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001) and 9.36 (AUROC 1.00, P<0.0001) in patients with HCV mono-infection and HBV dual-infection respectively. Among the HBV dually infected patients, the accuracy of anti-HCV titer in predicting HCV viremia reached up to 100% with the cut-off value of 9. All the patients were HCV-viremic if their anti-HCV titer was greater than 9 (PPV 100%). On the other hand, all the patients were HCV non-viremic if their anti-HCV titer was less than 9 (NPV 100%). CONCLUSIONS: Anti-HCV titer strongly predicted HCV viremia. This excellent performance could be generalized to either HCV mono-infected or HBV dually infected patients. Public Library of Science 2021-07-01 /pmc/articles/PMC8248640/ /pubmed/34197557 http://dx.doi.org/10.1371/journal.pone.0254028 Text en © 2021 Liu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liu, Hung-Yin Lin, Yi-Hung Lin, Pei-Ju Tsai, Pei-Chien Liu, Shu-Fen Huang, Ying-Chou Tsai, Jia-Jiun Huang, Ching-I Yeh, Ming-Lun Liang, Po-Cheng Lin, Zu-Yau Dai, Chia-Yen Huang, Jee-Fu Chuang, Wan-Long Huang, Chung-Feng Yu, Ming-Lung Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection |
title | Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection |
title_full | Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection |
title_fullStr | Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection |
title_full_unstemmed | Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection |
title_short | Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection |
title_sort | anti-hcv antibody titer highly predicts hcv viremia in patients with hepatitis b virus dual-infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248640/ https://www.ncbi.nlm.nih.gov/pubmed/34197557 http://dx.doi.org/10.1371/journal.pone.0254028 |
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