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Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of the highest fatality rates of any disease. There are many clinical signs and symptoms after ICH due to brain cell injury and network disruption resulted from the rupture of a tiny artery and activation of inflamma...

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Autores principales: Shi, Xiaoyu, Bai, Huiying, Wang, Junmin, Wang, Jiarui, Huang, Leo, He, Meimei, Zheng, Xuejun, Duan, Zitian, Chen, Danyang, Zhang, Jiaxin, Chen, Xuemei, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248664/
https://www.ncbi.nlm.nih.gov/pubmed/34220676
http://dx.doi.org/10.3389/fneur.2021.667511
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author Shi, Xiaoyu
Bai, Huiying
Wang, Junmin
Wang, Jiarui
Huang, Leo
He, Meimei
Zheng, Xuejun
Duan, Zitian
Chen, Danyang
Zhang, Jiaxin
Chen, Xuemei
Wang, Jian
author_facet Shi, Xiaoyu
Bai, Huiying
Wang, Junmin
Wang, Jiarui
Huang, Leo
He, Meimei
Zheng, Xuejun
Duan, Zitian
Chen, Danyang
Zhang, Jiaxin
Chen, Xuemei
Wang, Jian
author_sort Shi, Xiaoyu
collection PubMed
description Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of the highest fatality rates of any disease. There are many clinical signs and symptoms after ICH due to brain cell injury and network disruption resulted from the rupture of a tiny artery and activation of inflammatory cells, such as motor dysfunction, sensory impairment, cognitive impairment, and emotional disturbance, etc. Thus, researchers have established many tests to evaluate behavioral changes in rodent ICH models, in order to achieve a better understanding and thus improvements in the prognosis for the clinical treatment of stroke. This review summarizes existing protocols that have been applied to assess neurologic function outcomes in the rodent ICH models such as pain, motor, cognition, and emotion tests. Pain tests include mechanical, hot, and cold pain tests; motor tests include the following 12 types: neurologic deficit scale test, staircase test, rotarod test, cylinder test, grid walk test, forelimb placing test, wire hanging test, modified neurologic severity score, beam walking test, horizontal ladder test, and adhesive removal test; learning and memory tests include Morris water maze, Y-maze, and novel object recognition test; emotion tests include elevated plus maze, sucrose preference test, tail suspension test, open field test, and forced swim test. This review discusses these assessments by examining their rationale, setup, duration, baseline, procedures as well as comparing their pros and cons, thus guiding researchers to select the most appropriate behavioral tests for preclinical ICH research.
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spelling pubmed-82486642021-07-02 Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage Shi, Xiaoyu Bai, Huiying Wang, Junmin Wang, Jiarui Huang, Leo He, Meimei Zheng, Xuejun Duan, Zitian Chen, Danyang Zhang, Jiaxin Chen, Xuemei Wang, Jian Front Neurol Neurology Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of the highest fatality rates of any disease. There are many clinical signs and symptoms after ICH due to brain cell injury and network disruption resulted from the rupture of a tiny artery and activation of inflammatory cells, such as motor dysfunction, sensory impairment, cognitive impairment, and emotional disturbance, etc. Thus, researchers have established many tests to evaluate behavioral changes in rodent ICH models, in order to achieve a better understanding and thus improvements in the prognosis for the clinical treatment of stroke. This review summarizes existing protocols that have been applied to assess neurologic function outcomes in the rodent ICH models such as pain, motor, cognition, and emotion tests. Pain tests include mechanical, hot, and cold pain tests; motor tests include the following 12 types: neurologic deficit scale test, staircase test, rotarod test, cylinder test, grid walk test, forelimb placing test, wire hanging test, modified neurologic severity score, beam walking test, horizontal ladder test, and adhesive removal test; learning and memory tests include Morris water maze, Y-maze, and novel object recognition test; emotion tests include elevated plus maze, sucrose preference test, tail suspension test, open field test, and forced swim test. This review discusses these assessments by examining their rationale, setup, duration, baseline, procedures as well as comparing their pros and cons, thus guiding researchers to select the most appropriate behavioral tests for preclinical ICH research. Frontiers Media S.A. 2021-06-17 /pmc/articles/PMC8248664/ /pubmed/34220676 http://dx.doi.org/10.3389/fneur.2021.667511 Text en Copyright © 2021 Shi, Bai, Wang, Wang, Huang, He, Zheng, Duan, Chen, Zhang, Chen and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Shi, Xiaoyu
Bai, Huiying
Wang, Junmin
Wang, Jiarui
Huang, Leo
He, Meimei
Zheng, Xuejun
Duan, Zitian
Chen, Danyang
Zhang, Jiaxin
Chen, Xuemei
Wang, Jian
Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
title Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
title_full Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
title_fullStr Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
title_full_unstemmed Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
title_short Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
title_sort behavioral assessment of sensory, motor, emotion, and cognition in rodent models of intracerebral hemorrhage
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248664/
https://www.ncbi.nlm.nih.gov/pubmed/34220676
http://dx.doi.org/10.3389/fneur.2021.667511
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