Stepwise Induction of Inner Ear Hair Cells From Mouse Embryonic Fibroblasts via Mesenchymal- to-Epithelial Transition and Formation of Otic Epithelial Cells

Although embryonic stem cells or induced pluripotent stem cells are able to differentiate into inner ear hair cells (HCs), they have drawbacks limiting their clinical application, including a potential risk of tumourigenicity. Direct reprogramming of fibroblasts to inner ear HCs could offer an alter...

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Detalles Bibliográficos
Autores principales: Yang, Qiong, Shi, Haosong, Quan, Yizhou, Chen, Qianqian, Li, Wang, Wang, Li, Wang, Yonghui, Ji, Zhongzhong, Yin, Shan-Kai, Shi, Hai-Bo, Xu, Huiming, Gao, Wei-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248816/
https://www.ncbi.nlm.nih.gov/pubmed/34222247
http://dx.doi.org/10.3389/fcell.2021.672406

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