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Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease

Patients with sickle cell disease (SCD) are at high risk of developing serious infections, therefore, understanding the impact that severe acute respiratory syndrome coronavirus 2 infection has on this population is important. We sought to identify factors associated with hospitalization and serious...

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Autores principales: Mucalo, Lana, Brandow, Amanda M., Dasgupta, Mahua, Mason, Sadie F., Simpson, Pippa M., Singh, Ashima, Taylor, Bradley W., Woods, Katherine J., Yusuf, Fouza I., Panepinto, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248962/
https://www.ncbi.nlm.nih.gov/pubmed/34196678
http://dx.doi.org/10.1182/bloodadvances.2021004288
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author Mucalo, Lana
Brandow, Amanda M.
Dasgupta, Mahua
Mason, Sadie F.
Simpson, Pippa M.
Singh, Ashima
Taylor, Bradley W.
Woods, Katherine J.
Yusuf, Fouza I.
Panepinto, Julie A.
author_facet Mucalo, Lana
Brandow, Amanda M.
Dasgupta, Mahua
Mason, Sadie F.
Simpson, Pippa M.
Singh, Ashima
Taylor, Bradley W.
Woods, Katherine J.
Yusuf, Fouza I.
Panepinto, Julie A.
author_sort Mucalo, Lana
collection PubMed
description Patients with sickle cell disease (SCD) are at high risk of developing serious infections, therefore, understanding the impact that severe acute respiratory syndrome coronavirus 2 infection has on this population is important. We sought to identify factors associated with hospitalization and serious COVID-19 illness in children and adults with SCD.We established the international SECURE-SCD Registry to collect data on patients with SCD and COVID-19 illness. We used multivariable logistic models to estimate the independent effects of age, sex, genotype, hydroxyurea, and SCD-related and -nonrelated comorbidities on hospitalization, serious COVID-19 illness, and pain as a presenting symptom during COVID-19 illness. As of 23 March 2021, 750 COVID-19 illness cases in patients with SCD were reported to the registry. We identified history of pain (relative risk [RR], 2.15; P < .0001) and SCD heart/lung comorbidities (RR, 1.61; P = .0001) as risk factors for hospitalization in children. History of pain (RR, 1.78; P = .002) was also a risk factor for hospitalization in adults. Children with history of pain (RR, 3.09; P = .009), SCD heart/lung comorbidities (RR, 1.76; P = .03), and SCD renal comorbidities (RR, 3.67; P < .0001) and adults with history of pain (RR 1.94, P = .02) were at higher risk of developing serious COVID-19 illness. History of pain and SCD renal comorbidities also increased risk of pain during COVID-19 in children; history of pain, SCD heart/lung comorbidities, and female sex increased risk of pain during COVID-19 in adults. Hydroxyurea showed no effect on hospitalization and COVID-19 severity, but it lowered the risk of presenting with pain in adults during COVID-19.
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spelling pubmed-82489622021-07-02 Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease Mucalo, Lana Brandow, Amanda M. Dasgupta, Mahua Mason, Sadie F. Simpson, Pippa M. Singh, Ashima Taylor, Bradley W. Woods, Katherine J. Yusuf, Fouza I. Panepinto, Julie A. Blood Adv Clinical Trials and Observations Patients with sickle cell disease (SCD) are at high risk of developing serious infections, therefore, understanding the impact that severe acute respiratory syndrome coronavirus 2 infection has on this population is important. We sought to identify factors associated with hospitalization and serious COVID-19 illness in children and adults with SCD.We established the international SECURE-SCD Registry to collect data on patients with SCD and COVID-19 illness. We used multivariable logistic models to estimate the independent effects of age, sex, genotype, hydroxyurea, and SCD-related and -nonrelated comorbidities on hospitalization, serious COVID-19 illness, and pain as a presenting symptom during COVID-19 illness. As of 23 March 2021, 750 COVID-19 illness cases in patients with SCD were reported to the registry. We identified history of pain (relative risk [RR], 2.15; P < .0001) and SCD heart/lung comorbidities (RR, 1.61; P = .0001) as risk factors for hospitalization in children. History of pain (RR, 1.78; P = .002) was also a risk factor for hospitalization in adults. Children with history of pain (RR, 3.09; P = .009), SCD heart/lung comorbidities (RR, 1.76; P = .03), and SCD renal comorbidities (RR, 3.67; P < .0001) and adults with history of pain (RR 1.94, P = .02) were at higher risk of developing serious COVID-19 illness. History of pain and SCD renal comorbidities also increased risk of pain during COVID-19 in children; history of pain, SCD heart/lung comorbidities, and female sex increased risk of pain during COVID-19 in adults. Hydroxyurea showed no effect on hospitalization and COVID-19 severity, but it lowered the risk of presenting with pain in adults during COVID-19. American Society of Hematology 2021-07-01 /pmc/articles/PMC8248962/ /pubmed/34196678 http://dx.doi.org/10.1182/bloodadvances.2021004288 Text en © 2021 by The American Society of Hematology
spellingShingle Clinical Trials and Observations
Mucalo, Lana
Brandow, Amanda M.
Dasgupta, Mahua
Mason, Sadie F.
Simpson, Pippa M.
Singh, Ashima
Taylor, Bradley W.
Woods, Katherine J.
Yusuf, Fouza I.
Panepinto, Julie A.
Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease
title Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease
title_full Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease
title_fullStr Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease
title_full_unstemmed Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease
title_short Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease
title_sort comorbidities are risk factors for hospitalization and serious covid-19 illness in children and adults with sickle cell disease
topic Clinical Trials and Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248962/
https://www.ncbi.nlm.nih.gov/pubmed/34196678
http://dx.doi.org/10.1182/bloodadvances.2021004288
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