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Genetic variant in 3’ untranslated region of the mouse pycard gene regulates inflammasome activity

Quantitative trait locus mapping for interleukin-1β release after inflammasome priming and activation was performed on bone-marrow-derived macrophages (BMDM) from an AKRxDBA/2 mouse strain intercross. The strongest associated locus mapped very close to the Pycard gene on chromosome 7, which codes fo...

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Detalles Bibliográficos
Autores principales:	Ritchey, Brian, Hai, Qimin, Han, Juying, Barnard, John, Smith, Jonathan D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248980/ https://www.ncbi.nlm.nih.gov/pubmed/34197316 http://dx.doi.org/10.7554/eLife.68203

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