Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type, and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived fr...

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Detalles Bibliográficos
Autores principales: Findley, Anthony S, Monziani, Alan, Richards, Allison L, Rhodes, Katherine, Ward, Michelle C, Kalita, Cynthia A, Alazizi, Adnan, Pazokitoroudi, Ali, Sankararaman, Sriram, Wen, Xiaoquan, Lanfear, David E, Pique-Regi, Roger, Gilad, Yoav, Luca, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248987/
https://www.ncbi.nlm.nih.gov/pubmed/33988505
http://dx.doi.org/10.7554/eLife.67077

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