A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

ER proteins of widely differing abundance are retrieved from the Golgi by the KDEL-receptor. Abundant ER proteins tend to have KDEL rather than HDEL signals, whereas ADEL and DDEL are not used in most organisms. Here, we explore the mechanism of selective retrieval signal capture by the KDEL-recepto...

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Detalles Bibliográficos
Autores principales: Gerondopoulos, Andreas, Bräuer, Philipp, Sobajima, Tomoaki, Wu, Zhiyi, Parker, Joanne L, Biggin, Philip C, Barr, Francis A, Newstead, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248988/
https://www.ncbi.nlm.nih.gov/pubmed/34137369
http://dx.doi.org/10.7554/eLife.68380

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