Cargando…

Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons

Acquired immune deficiency syndrome (AIDS) is a major public health problem affecting several countries with predominance in black Africa. Faced with therapeutic failure caused by resistance and supply disruptions, searching for other antiretroviral agents, in particular from natural sources, become...

Descripción completa

Detalles Bibliográficos
Autores principales: Goni Hamadama, Oumarou, Leonel Javeres, Mbah Ntepe, Nyemb, Nyunaï, Mba Fabrice, Medou, Manuela Elsa, Pettang Tomen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249164/
https://www.ncbi.nlm.nih.gov/pubmed/34257647
http://dx.doi.org/10.1155/2021/5594505
_version_ 1783716855043588096
author Goni Hamadama, Oumarou
Leonel Javeres, Mbah Ntepe
Nyemb, Nyunaï
Mba Fabrice, Medou
Manuela Elsa, Pettang Tomen
author_facet Goni Hamadama, Oumarou
Leonel Javeres, Mbah Ntepe
Nyemb, Nyunaï
Mba Fabrice, Medou
Manuela Elsa, Pettang Tomen
author_sort Goni Hamadama, Oumarou
collection PubMed
description Acquired immune deficiency syndrome (AIDS) is a major public health problem affecting several countries with predominance in black Africa. Faced with therapeutic failure caused by resistance and supply disruptions, searching for other antiretroviral agents, in particular from natural sources, becomes necessary. Given popular consumption of Azadirachta indica and Senna siamea decoction in the Northern Cameroon region and the traditionally attributed antiretroviral value, information on its efficacy and safety consumption is relevant to confirm its use. A total of 297 participants aged 18–52 and HIV-positive were recruited and divided into 3 groups: one taking only the decoction (group 1), another taking only antiretroviral therapy (ARTs) (group 2), and finally, one taking the decoction and antiretroviral (group 3). During 6 months, all the participants of the concerned groups consumed daily (morning and evening) 250 mL of Azadirachta indica and Senna siamea decoction. CD4+ and CD8+ levels were measured by flow cytometry. Hepatic and renal toxicity and oxidative stress were evaluated spectrophotometrically by measuring ALT, AST, ALP, BUN, CREAT, SOD, CAT, and GSH parameters. We note an increase in the CD4+ level of the three groups with values much more pronounced in the group treated by ARTs + decoction, from 328 ± 106 to 752 ± 140. Group 2 presented not only biological signs of hepatic and renal toxicity but also significant oxidative stress. No signs of toxicity were detected in the other groups. The study concludes that a decoction of Azadirachta indica and Senna siamea stimulates the production of CD4+ and is not toxic. On the contrary, it would reduce the toxicity caused by ARTs intake.
format Online
Article
Text
id pubmed-8249164
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-82491642021-07-12 Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons Goni Hamadama, Oumarou Leonel Javeres, Mbah Ntepe Nyemb, Nyunaï Mba Fabrice, Medou Manuela Elsa, Pettang Tomen J Toxicol Research Article Acquired immune deficiency syndrome (AIDS) is a major public health problem affecting several countries with predominance in black Africa. Faced with therapeutic failure caused by resistance and supply disruptions, searching for other antiretroviral agents, in particular from natural sources, becomes necessary. Given popular consumption of Azadirachta indica and Senna siamea decoction in the Northern Cameroon region and the traditionally attributed antiretroviral value, information on its efficacy and safety consumption is relevant to confirm its use. A total of 297 participants aged 18–52 and HIV-positive were recruited and divided into 3 groups: one taking only the decoction (group 1), another taking only antiretroviral therapy (ARTs) (group 2), and finally, one taking the decoction and antiretroviral (group 3). During 6 months, all the participants of the concerned groups consumed daily (morning and evening) 250 mL of Azadirachta indica and Senna siamea decoction. CD4+ and CD8+ levels were measured by flow cytometry. Hepatic and renal toxicity and oxidative stress were evaluated spectrophotometrically by measuring ALT, AST, ALP, BUN, CREAT, SOD, CAT, and GSH parameters. We note an increase in the CD4+ level of the three groups with values much more pronounced in the group treated by ARTs + decoction, from 328 ± 106 to 752 ± 140. Group 2 presented not only biological signs of hepatic and renal toxicity but also significant oxidative stress. No signs of toxicity were detected in the other groups. The study concludes that a decoction of Azadirachta indica and Senna siamea stimulates the production of CD4+ and is not toxic. On the contrary, it would reduce the toxicity caused by ARTs intake. Hindawi 2021-06-23 /pmc/articles/PMC8249164/ /pubmed/34257647 http://dx.doi.org/10.1155/2021/5594505 Text en Copyright © 2021 Oumarou Goni Hamadama et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Goni Hamadama, Oumarou
Leonel Javeres, Mbah Ntepe
Nyemb, Nyunaï
Mba Fabrice, Medou
Manuela Elsa, Pettang Tomen
Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons
title Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons
title_full Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons
title_fullStr Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons
title_full_unstemmed Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons
title_short Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons
title_sort effect of azadirachta indica and senna siamea decoction on cd4+ and cd8+ level, toxicological, and antioxidant profile in hiv/aids positive persons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249164/
https://www.ncbi.nlm.nih.gov/pubmed/34257647
http://dx.doi.org/10.1155/2021/5594505
work_keys_str_mv AT gonihamadamaoumarou effectofazadirachtaindicaandsennasiameadecoctiononcd4andcd8leveltoxicologicalandantioxidantprofileinhivaidspositivepersons
AT leoneljaveresmbahntepe effectofazadirachtaindicaandsennasiameadecoctiononcd4andcd8leveltoxicologicalandantioxidantprofileinhivaidspositivepersons
AT nyembnyunai effectofazadirachtaindicaandsennasiameadecoctiononcd4andcd8leveltoxicologicalandantioxidantprofileinhivaidspositivepersons
AT mbafabricemedou effectofazadirachtaindicaandsennasiameadecoctiononcd4andcd8leveltoxicologicalandantioxidantprofileinhivaidspositivepersons
AT manuelaelsapettangtomen effectofazadirachtaindicaandsennasiameadecoctiononcd4andcd8leveltoxicologicalandantioxidantprofileinhivaidspositivepersons