High-resolution characterization of gene function using single-cell CRISPR tiling screen

Identification of novel functional domains and characterization of detailed regulatory mechanisms in cancer-driving genes is critical for advanced cancer therapy. To date, CRISPR gene editing has primarily been applied to defining the role of individual genes. Recently, high-density mutagenesis via...

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Detalles Bibliográficos
Autores principales: Yang, Lu, Chan, Anthony K. N., Miyashita, Kazuya, Delaney, Christopher D., Wang, Xi, Li, Hongzhi, Pokharel, Sheela Pangeni, Li, Sandra, Li, Mingli, Xu, Xiaobao, Lu, Wei, Liu, Qiao, Mattson, Nicole, Chen, Kevin Yining, Wang, Jinhui, Yuan, Yate-Ching, Horne, David, Rosen, Steven T., Soto-Feliciano, Yadira, Feng, Zhaohui, Hoshii, Takayuki, Xiao, Gang, Müschen, Markus, Chen, Jianjun, Armstrong, Scott A., Chen, Chun-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249386/
https://www.ncbi.nlm.nih.gov/pubmed/34210975
http://dx.doi.org/10.1038/s41467-021-24324-0

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