Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant

The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we confirmed that the aspartate replacement by glycine in position 614 is markedly more infectious. Molecular modelling suggests that the G614 mutati...

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Detalles Bibliográficos
Autores principales: Ilmjärv, Sten, Abdul, Fabien, Acosta-Gutiérrez, Silvia, Estarellas, Carolina, Galdadas, Ioannis, Casimir, Marina, Alessandrini, Marco, Gervasio, Francesco Luigi, Krause, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249556/
https://www.ncbi.nlm.nih.gov/pubmed/34210996
http://dx.doi.org/10.1038/s41598-021-91662-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249556/
https://www.ncbi.nlm.nih.gov/pubmed/34210996
http://dx.doi.org/10.1038/s41598-021-91662-w

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