Cargando…
The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg
Objective: This study aims to investigate the effect of optimized ultrafiltration on perioperative electrolytes, acid–base balance, and pulmonary function during cardiopulmonary bypass (CPB) in infants with low body weight (under 10 kg), using traditional balanced ultrafiltration and modified ultraf...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249567/ https://www.ncbi.nlm.nih.gov/pubmed/34222139 http://dx.doi.org/10.3389/fped.2021.602034 |
_version_ | 1783716923109801984 |
---|---|
author | Niu, Jianhong Zhai, Guangdi Zheng, Aibin Zhou, Juanying Jiang, Shengqi Ma, Jianping |
author_facet | Niu, Jianhong Zhai, Guangdi Zheng, Aibin Zhou, Juanying Jiang, Shengqi Ma, Jianping |
author_sort | Niu, Jianhong |
collection | PubMed |
description | Objective: This study aims to investigate the effect of optimized ultrafiltration on perioperative electrolytes, acid–base balance, and pulmonary function during cardiopulmonary bypass (CPB) in infants with low body weight (under 10 kg), using traditional balanced ultrafiltration and modified ultrafiltration. Methods: A total of 30 children who underwent surgical correction for congenital heart disease in Changzhou Children's Hospital between January 2018 and December 2019 were randomly divided into two groups. In the treatment group, ultrafiltration pre-treatment was carried out with blood-containing priming fluid prior to CPB. Balanced ultrafiltration was performed during the operation, and optimized and modified ultrafiltration were conducted before closing and extubation. In the control group, traditional balanced ultrafiltration was used during the operation, and a modified ultrafiltration combination was used before closing and extubation. Indexes such as blood gas analysis and electrolytes were measured perioperatively, and pulmonary function was observed. Results: No deaths were reported in either group. The ventilator-assisted breathing time was shorter in the treatment group than in the control group (P < 0.05). The indexes of the treatment group were closer than those of the control group to the optimal physiological values. The concentrations of potassium ion (K(+)), lactate (Lac), and blood glucose (Glu) decreased, and there was significant difference between the two groups (P < 0.05) at the end of CPB. Hemoglobin (Hb) and hematocrit (HCT) in the treatment group increased (P < 0.01). Alveolar-arterial differences for oxygen (A-aDO(2)) and respiratory index (RI) increased significantly in both groups after operation. Children in the treatment group began to recover lung function earlier than children in the control group. Both A-aDO(2) and RI were lower in the treatment group than in the control group at each time point after operation (P < 0.05). Conclusion: Optimizing and modifying the traditional ultrafiltration combination method can effectively shorten the ultrafiltration time, reduce the adverse impacts of the ultrafiltration technique, and improve the lung function of infants after operation. |
format | Online Article Text |
id | pubmed-8249567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82495672021-07-03 The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg Niu, Jianhong Zhai, Guangdi Zheng, Aibin Zhou, Juanying Jiang, Shengqi Ma, Jianping Front Pediatr Pediatrics Objective: This study aims to investigate the effect of optimized ultrafiltration on perioperative electrolytes, acid–base balance, and pulmonary function during cardiopulmonary bypass (CPB) in infants with low body weight (under 10 kg), using traditional balanced ultrafiltration and modified ultrafiltration. Methods: A total of 30 children who underwent surgical correction for congenital heart disease in Changzhou Children's Hospital between January 2018 and December 2019 were randomly divided into two groups. In the treatment group, ultrafiltration pre-treatment was carried out with blood-containing priming fluid prior to CPB. Balanced ultrafiltration was performed during the operation, and optimized and modified ultrafiltration were conducted before closing and extubation. In the control group, traditional balanced ultrafiltration was used during the operation, and a modified ultrafiltration combination was used before closing and extubation. Indexes such as blood gas analysis and electrolytes were measured perioperatively, and pulmonary function was observed. Results: No deaths were reported in either group. The ventilator-assisted breathing time was shorter in the treatment group than in the control group (P < 0.05). The indexes of the treatment group were closer than those of the control group to the optimal physiological values. The concentrations of potassium ion (K(+)), lactate (Lac), and blood glucose (Glu) decreased, and there was significant difference between the two groups (P < 0.05) at the end of CPB. Hemoglobin (Hb) and hematocrit (HCT) in the treatment group increased (P < 0.01). Alveolar-arterial differences for oxygen (A-aDO(2)) and respiratory index (RI) increased significantly in both groups after operation. Children in the treatment group began to recover lung function earlier than children in the control group. Both A-aDO(2) and RI were lower in the treatment group than in the control group at each time point after operation (P < 0.05). Conclusion: Optimizing and modifying the traditional ultrafiltration combination method can effectively shorten the ultrafiltration time, reduce the adverse impacts of the ultrafiltration technique, and improve the lung function of infants after operation. Frontiers Media S.A. 2021-06-18 /pmc/articles/PMC8249567/ /pubmed/34222139 http://dx.doi.org/10.3389/fped.2021.602034 Text en Copyright © 2021 Niu, Zhai, Zheng, Zhou, Jiang and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Niu, Jianhong Zhai, Guangdi Zheng, Aibin Zhou, Juanying Jiang, Shengqi Ma, Jianping The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg |
title | The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg |
title_full | The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg |
title_fullStr | The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg |
title_full_unstemmed | The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg |
title_short | The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg |
title_sort | effect of optimized ultrafiltration on perioperative pulmonary function during cardiopulmonary bypass in infants under 10 kg |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249567/ https://www.ncbi.nlm.nih.gov/pubmed/34222139 http://dx.doi.org/10.3389/fped.2021.602034 |
work_keys_str_mv | AT niujianhong theeffectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT zhaiguangdi theeffectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT zhengaibin theeffectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT zhoujuanying theeffectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT jiangshengqi theeffectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT majianping theeffectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT niujianhong effectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT zhaiguangdi effectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT zhengaibin effectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT zhoujuanying effectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT jiangshengqi effectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg AT majianping effectofoptimizedultrafiltrationonperioperativepulmonaryfunctionduringcardiopulmonarybypassininfantsunder10kg |