Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antib...

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Detalles Bibliográficos
Autores principales: Han, Yiwen, Liu, Zhaoxia, Chen, Tingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249587/
https://www.ncbi.nlm.nih.gov/pubmed/34220737
http://dx.doi.org/10.3389/fmicb.2021.643422
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author Han, Yiwen
Liu, Zhaoxia
Chen, Tingtao
author_facet Han, Yiwen
Liu, Zhaoxia
Chen, Tingtao
author_sort Han, Yiwen
collection PubMed
description Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.
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spelling pubmed-82495872021-07-03 Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions Han, Yiwen Liu, Zhaoxia Chen, Tingtao Front Microbiol Microbiology Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions. Frontiers Media S.A. 2021-06-18 /pmc/articles/PMC8249587/ /pubmed/34220737 http://dx.doi.org/10.3389/fmicb.2021.643422 Text en Copyright © 2021 Han, Liu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Han, Yiwen
Liu, Zhaoxia
Chen, Tingtao
Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
title Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
title_full Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
title_fullStr Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
title_full_unstemmed Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
title_short Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
title_sort role of vaginal microbiota dysbiosis in gynecological diseases and the potential interventions
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249587/
https://www.ncbi.nlm.nih.gov/pubmed/34220737
http://dx.doi.org/10.3389/fmicb.2021.643422
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AT chentingtao roleofvaginalmicrobiotadysbiosisingynecologicaldiseasesandthepotentialinterventions

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