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SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a highly prevalent infectious disease. Currently, organs are not being transplanted from donors who are SARS-CoV-2 positive. It remains unclear as to how to differentiate active from recovered patients. We report our recent expe...

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Autores principales: Nelson, Susan, Curran, Christopher C., Sutcliffe, David L., Rofaiel, George, Chang, Yeh-Chung, Easterling, Larry, Wood, R. Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249701/
https://www.ncbi.nlm.nih.gov/pubmed/34301402
http://dx.doi.org/10.1016/j.transproceed.2021.06.028
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author Nelson, Susan
Curran, Christopher C.
Sutcliffe, David L.
Rofaiel, George
Chang, Yeh-Chung
Easterling, Larry
Wood, R. Patrick
author_facet Nelson, Susan
Curran, Christopher C.
Sutcliffe, David L.
Rofaiel, George
Chang, Yeh-Chung
Easterling, Larry
Wood, R. Patrick
author_sort Nelson, Susan
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a highly prevalent infectious disease. Currently, organs are not being transplanted from donors who are SARS-CoV-2 positive. It remains unclear as to how to differentiate active from recovered patients. We report our recent experience of a 3-month-old deceased organ donor who died as the result of an anoxic brain injury after a cardiopulmonary arrest (presumed sudden infant death syndrome). The child was born to a mother presumed to have coronavirus disease 2019. The donor tested negative for SARS-CoV-2 reverse transcriptase–polymerase chain reaction and positive for SARS-CoV-2 immunoglobulin A antibodies. We suspect this is the first known report of its kind and noteworthy for the organ donation and transplantation community.
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spelling pubmed-82497012021-07-02 SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature Nelson, Susan Curran, Christopher C. Sutcliffe, David L. Rofaiel, George Chang, Yeh-Chung Easterling, Larry Wood, R. Patrick Transplant Proc Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a highly prevalent infectious disease. Currently, organs are not being transplanted from donors who are SARS-CoV-2 positive. It remains unclear as to how to differentiate active from recovered patients. We report our recent experience of a 3-month-old deceased organ donor who died as the result of an anoxic brain injury after a cardiopulmonary arrest (presumed sudden infant death syndrome). The child was born to a mother presumed to have coronavirus disease 2019. The donor tested negative for SARS-CoV-2 reverse transcriptase–polymerase chain reaction and positive for SARS-CoV-2 immunoglobulin A antibodies. We suspect this is the first known report of its kind and noteworthy for the organ donation and transplantation community. Elsevier Inc. 2021-10 2021-07-02 /pmc/articles/PMC8249701/ /pubmed/34301402 http://dx.doi.org/10.1016/j.transproceed.2021.06.028 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nelson, Susan
Curran, Christopher C.
Sutcliffe, David L.
Rofaiel, George
Chang, Yeh-Chung
Easterling, Larry
Wood, R. Patrick
SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature
title SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature
title_full SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature
title_fullStr SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature
title_full_unstemmed SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature
title_short SARS-CoV-2 Antibody Serology Testing in a 3-Month-Old Organ Donor: A Case Report and Review of Available Literature
title_sort sars-cov-2 antibody serology testing in a 3-month-old organ donor: a case report and review of available literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249701/
https://www.ncbi.nlm.nih.gov/pubmed/34301402
http://dx.doi.org/10.1016/j.transproceed.2021.06.028
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