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Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease

In December 2019, the first case of coronavirus disease (COVID-19) was first reported in Wuhan, China. As of March 2021, there were more than 120 million confirmed cases of COVID-19 and 2.7 million deaths. The COVID-19 mortality rate in adults is around 1–5%, and only a small proportion of children...

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Autores principales: Lee, Min-Sheng, Liu, Yi-Ching, Tsai, Ching-Chung, Hsu, Jong-Hau, Wu, Jiunn-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249705/
https://www.ncbi.nlm.nih.gov/pubmed/34222140
http://dx.doi.org/10.3389/fped.2021.640118
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author Lee, Min-Sheng
Liu, Yi-Ching
Tsai, Ching-Chung
Hsu, Jong-Hau
Wu, Jiunn-Ren
author_facet Lee, Min-Sheng
Liu, Yi-Ching
Tsai, Ching-Chung
Hsu, Jong-Hau
Wu, Jiunn-Ren
author_sort Lee, Min-Sheng
collection PubMed
description In December 2019, the first case of coronavirus disease (COVID-19) was first reported in Wuhan, China. As of March 2021, there were more than 120 million confirmed cases of COVID-19 and 2.7 million deaths. The COVID-19 mortality rate in adults is around 1–5%, and only a small proportion of children requires hospitalization and intensive care. Recently, an increasing number of COVID-19 cases in children have been associated with a new multisystem inflammatory syndrome. Its clinical features and laboratory characteristics are similar to those of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome. However, this new disorder has some distinct clinical features and laboratory characteristics. This condition, also known as multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, has been observed mostly in Europe and the United States. This emerging phenomenon has raised the question of whether this disorder is KD triggered by SARS-CoV-2 or a syndrome characterized by multisystem inflammation that mimics KD. This narrative review is to discuss the differences between MIS-C and KD with the aim of increasing pediatricians' awareness of this new condition and guide them in the process of differential diagnosis.
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spelling pubmed-82497052021-07-03 Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease Lee, Min-Sheng Liu, Yi-Ching Tsai, Ching-Chung Hsu, Jong-Hau Wu, Jiunn-Ren Front Pediatr Pediatrics In December 2019, the first case of coronavirus disease (COVID-19) was first reported in Wuhan, China. As of March 2021, there were more than 120 million confirmed cases of COVID-19 and 2.7 million deaths. The COVID-19 mortality rate in adults is around 1–5%, and only a small proportion of children requires hospitalization and intensive care. Recently, an increasing number of COVID-19 cases in children have been associated with a new multisystem inflammatory syndrome. Its clinical features and laboratory characteristics are similar to those of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome. However, this new disorder has some distinct clinical features and laboratory characteristics. This condition, also known as multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, has been observed mostly in Europe and the United States. This emerging phenomenon has raised the question of whether this disorder is KD triggered by SARS-CoV-2 or a syndrome characterized by multisystem inflammation that mimics KD. This narrative review is to discuss the differences between MIS-C and KD with the aim of increasing pediatricians' awareness of this new condition and guide them in the process of differential diagnosis. Frontiers Media S.A. 2021-06-18 /pmc/articles/PMC8249705/ /pubmed/34222140 http://dx.doi.org/10.3389/fped.2021.640118 Text en Copyright © 2021 Lee, Liu, Tsai, Hsu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Lee, Min-Sheng
Liu, Yi-Ching
Tsai, Ching-Chung
Hsu, Jong-Hau
Wu, Jiunn-Ren
Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
title Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
title_full Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
title_fullStr Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
title_full_unstemmed Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
title_short Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
title_sort similarities and differences between covid-19-related multisystem inflammatory syndrome in children and kawasaki disease
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249705/
https://www.ncbi.nlm.nih.gov/pubmed/34222140
http://dx.doi.org/10.3389/fped.2021.640118
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